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Pharmacological particulars
Pharmacotherapeutic group: Antibacterial for systemic use.
ATCVet Code: QJ01XQ01
Pharmacodynamic properties
The following organisms show sensitivity to tiamulin in vitro:
Brachyspira: Brachyspira hyodysenteriae, Brachyspira pilosicoli
Mycoplasmas: Mycoplasma hyopneumoniae, M. hyorhinis, M. hyosynoviae, M. dispar,Ureaplasma spp,Gram-positive: Staphylococcus spp., Streptococcus spp., Corynebacterium pyogenes.
Gram-negative: Pasteurella spp., Klebsiella pneumoniae, Actinobacillus (Haemophilus)spp., Fusobacterium necrophorum, Bacteroides spp., Campylobacter coli,Lawsonia intracellularis.
Pharmacokinetic particulars
Following oral administration the active ingredient, tiamulin, is rapidly absorbed, peak serum levels being achieved within two hours. Tiamulin distributes widely in tissues, including the colon. High tiamulin concentrations are found in the lung of up to approximately 20 times the value found in the serum. Two hours post-injection, tiamulin lung levels of 14.5 – 16.7 mg/g have been found.