ATC Vet Code: QP52AE51
Pharmacotherapeutic group: Anthelmintics, Imidazothiazoles
Pharmacodynamic properties
Levamisole is an anthelmintic acting by causing muscular paralysis and expulsion of the nematode. Triclabendazole is a flukicide, highly active against all life stages of Fasciola from 2 weeks.
Pharmacokinetic particulars
Majority of triclabendazole oral dose in rats, sheep, goats and rabbits is eliminated in faeces after 6-10 days, as unchanged drug or products of biliary excretion. Urinary excretion is minimal. Sulphone, sulphoxide, ketone and 4-hydroxy triclabendazole derivatives are the main metabolites identified in plasma. Levamisole is rapidly absorbed after oral administration, is extensively metabolised and by 8 days after application excretion is virtually complete.