Indications for use, specifying the target species
Indicated in the treatment and control of diseases caused by or associated with bacterial pathogens sensitive to ampicillin. These include the following groups of pathogens:
Streptococcus spp., Pasturella haemolitica, P. multocida, Staphylococcus aureus and other pathogenic staphylococci.
When susceptible organisms are present treatment may be effective in the following indications:
alimentary tract infections
urinary tract infections
Not to be administered to animals known to be sensitive to penicillin.
Not to be administered to small herbivores.
Do not treat dogs of less than 10 kg bodyweight.
Special warnings for each target species
As with all penicillins, the product may cause hypersensitivity (allergy) following ingestion. It should not be used when the dog is known to be allergic to penicillins.
As with all other penicillins, bacterial resistance to ampicillin may occur. Thus antibiotic sensitivity testing should be considered if a clinical condition fails to respond to treatment within 3 to 5 days.
Special precautions for use
i.Special precautions for use in animals
For oral administration only.
ii. Special precautions to be taken by the person administering the veterinary medicinal product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
1. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all recommended precautions.
3. If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention.
Wash hands after use.
Adverse reactions (frequency and seriousness)
Use during pregnancy, lactation or lay
No studies have been carried out on pregnant animals, but the evidence provided suggests that ampicillin does not present any particular hazard either to the dam or foetus.
Interaction with other medicinal products and other forms of interaction
Ampicillin is unlikely to interact significantly with any other drugs commonly administered to dogs. It is not recommended to administer bactericidal and bacteriostatic antibiotics concomitantly.
Amounts to be administered and administration route
Recommended dose: 10 - 20 mg/kg twice daily.
The higher dose levels are advised when treating infections due to Gram-negative bacteria and in cases involving young animals. Therapy should be repeated every 12 hours and continued for a maximum of 5 days. In severe or acute conditions, the dose levels may be increased.
To be given by the oral route only. The capsules should be administered on an empty stomach.
Overdose (symptoms, emergency procedures, antidotes) if necessary
The safety of ampicillin is typical of that of other penicillins in that intrinsic toxicity is very low, except in animals with specific allergy to the beta-lactams.