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Pharmacological particulars
Pharmacotherapeutic group: Propulsives. ATCvet code: QA03FA01
Pharmacodynamic properties
Metoclopramide is an original orthopramide molecule.
The anti-emetic action of metoclopramide is mainly due to its antagonist activity at D2 receptors in the central nervous system, preventing nausea and vomiting triggered by most stimuli.
The prokinetic effect on the gastro-duodenal transit (increase in intensity and rhythm of stomach contractions and opening of the pylorus) is mediated by muscarinic activity, D2 receptor antagonist activity and 5-HT4 receptor agonist activity at the gastro-intestinal level.
Pharmacokinetic particulars
Metoclopramide is rapidly and almost completely absorbed from the gastrointestinal tract following oral administration.
Metoclopramide is rapidly distributed into most tissues and fluids, crosses the blood-brain barrier and enters the central nervous system.
Metoclopramide is metabolised by the liver.
The elimination of metoclopramide is rapid, 65 % of the dose being eliminated within 24 hours in the dog, primarily by the urinary route.