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Pharmacological particulars
Ivermectin is an endectocidal macrocyclic lactone.
Triclabendazole is an anthelmintic benzimidazole.
ATCvet Code: QP54AA51
Pharmacodynamic properties
Avermectins interact with glutamate-gated chloride ion channels, to increase membrane permeability to chloride ions, causing irreversible neuromuscular blockade in nematodes and arthropods, followed by paralysis and death.
Triclabendazole interferes with intracellular transport mechanisms and inhibits protein synthesis and is active against the liver fluke Fasciola.
Pharmacokinetic particulars
Ivermectin is readily absorbed and reaches peak plasma concentrations within 1 day. Afterwards plasma concentrations decrease with a half life of up to 5 days.
Triclabendazole is readily absorbed, oxidised to triclabendazole sulfoxide and to triclabendazole sulfone. Peak plasma concentrations are reached within 2 days. Afterwards plasma concentrations decrease with a half life of about 1.5 days. Both metabolites bind strongly to plasma proteins, particularly albumin. More than 90 % of the dose is excreted in the feces, about 2 % in the urine and less than 1 % in the milk within 10 days. The inter-individual variability of the kinetics of ivermectin and metabolites of triclabendazole in ovine species is high.