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Pharmacological particulars
Pharmacotherapeutic group: Antibacterials for systemic use, other antibacterials. ATCvet code: QJ01XX04
Spectinomycin is an aminocyclitol antimicrobial and has been shown to be produced by two kinds of fungi, Streptomyces flavopersicus and Streptomyces spectabilis. It is similar to the aminoglycosides, acting by binding to ribosomal 30s subunits of the bacteria.
In-vitro tests have shown spectinomycin to be effective against a range of Gram-negative and Gram-positive bacteria, although in the field its spectrum of action is for Gram-negative bacteria. Anaerobic organisms are generally resistant.
It has been demonstrated that spectinomycin is more bacteriostatic than bactericidal. The mechanism of action appears to be by inhibition of protein synthesis.
Spectinomycin is poorly absorbed from the alimentary canal. In the blood, protein binding is low at less than 10%. It is almost totally eliminated by renal glomerular filtration with 75% or more cleared in 4 hours.