Target Species
Dogs, cats, puppies and kittens.
Indications for use
A broad spectrum anthelmintic for the treatment of domestic dogs and cats infected with immature and mature stages of nematodes of the gastrointestinal and respiratory tracts. The product also has an ovicidal effect on nematode eggs.
Adult dogs and cats: For the treatment of adult dogs and cats infected with gastrointestinal nematodes and cestodes:
Ascarid spp (Toxocara canis, Toxocara cati and Toxascaris leonina)
Ancylostoma spp
Trichuris spp
Uncinaria spp
Taenia spp
Puppies and kittens: For the treatment of puppies and kittens infected with gastro-intestinal nematodes and puppies infected with protozoa (Giardia spp).
Also for the treatment of dogs infected with lungworm Oslerus (Filaroides) osleri or protozoa Giardia spp and cats infected with lungworm Aelurostrongylus abstrusus.
Contraindications
None.
Special warnings for each target species
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
• Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
• Underdosing, which may be due to underestimation of bodyweight or misadministration of the product.
Special precautions for use
Assess bodyweight as accurately as possible before calculating the dosage.
Operator warnings
Direct contact with the skin should be kept to a minimum.
Personal protective equipment consisting of impermeable rubber gloves should be worn when handling the veterinary medicinal product.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.
Adverse Reactions
Dogs, cats, puppies and kittens:
Very rare (<1 animal / 10,000 animals treated, including isolated reports): | Gastrointestinal disorders (e.g. vomiting1 and diarrhoea1). |
1 mild
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Use during pregnancy or lactation
Pregnant females may be safely treated with fenbendazole at therapeutic dosage levels. Owing to the reduced dose rate for treatment of pregnant dogs (25 mg fenbendazole/kg bodyweight daily) which cannot accurately be attained when using the syringe, it is recommended that alternative formulations of fenbendazole be used.
Interactions
None known.
Amounts to be administered and administration route
Oral use.
The veterinary medicinal product should be administered orally by squeezing the paste from the syringe onto the back of the tongue after feeding.
Each injector contains 4.8 g paste, equivalent to 900 mg fenbendazole. To prepare the syringe for the first use, remove the syringe tip and turn the dial ring until the edge of the ring nearest the tip lines up with the zero (0) on the tube. Depress the plunger and discard any expelled paste. To protect householders, discard any unused paste into tissue and immediately dispose of via the household waste.
The syringe is ready for use. The plunger has 18 graduations, each unit corresponding to 50 mg fenbendazole. Determine the number of graduations needed based on the bodyweight of the animal. Turn the ring on the plunger to the corresponding graduation.
Adult Cats and Dogs
Orally administer 2 syringe graduations per 1 kg bodyweight as a single dose (= 100 mg fenbendazole/kg bodyweight). Each syringe is sufficient to dose up to 9 kg bodyweight as a single dose.
Practical dosage recommendations:
Up to 1kg 2 syringe graduations
1.1 to 2 kg 4 syringe graduations
2.1 to 3 kg 6 syringe graduations
3.1 to 4 kg 8 syringe graduations
4.1 to 5 kg 10 syringe graduations
5.1 to 6 kg 12 syringe graduations
6.1 to 7 kg 14 syringe graduations
7.1 to 8 kg 16 syringe graduations
8.1 to 9 kg 18 syringe graduations
Additional syringes are required for dogs and cats weighing over 9 kg. For dogs and cats weighing over 9 kg, two extra syringe graduations are required for each additional 1 kg bodyweight as a single dose.
Treatment should be repeated when natural reinfection with parasitic worms occurs.
Routine treatment of adult animals with minimal exposure to infection is advisable 2 to 4 times per year. More frequent treatment at 6 to 8 weekly intervals is advisable for dogs in kennels and cats in catteries or a breeder’s premises.
Puppies and kittens under 6 months of age
Only treat puppies and kittens weighing greater than 1 kg with this product.
Orally administer the recommended dosages as described below, daily for 3 consecutive days.
Each syringe is sufficient to dose up to 6 kg bodyweight for 3 consecutive days.
Practical dosage recommendations:
1.0 to 2 kg 2 syringe graduations daily for 3 days
2.1 to 3 kg 3 syringe graduations daily for 3 days
3.1 to 4 kg 4 syringe graduations daily for 3 days
4.1 to 5 kg 5 syringe graduations daily for 3 days
5.1 to 6 kg 6 syringe graduations daily for 3 days
Additional syringes are required if puppies weigh over 6 kg under 6 months old.
For puppies weighing over 6 kg, an extra syringe graduation is required daily for each additional 1 kg bodyweight.
Puppies and kittens should be treated at 2 weeks of age, 5 weeks of age and again before leaving the breeder’s premises. Treatment may also be required at 8 and 12 weeks of age. Thereafter, frequency of treatment can be reduced unless the puppies and kittens remain in kennels or kittens remain in catteries /breeder’s premises where reinfection occurs more readily.
Pregnant dogs
Owing to the reduced dose rate for treatment of pregnant dogs (25 mg fenbendazole/kg bodyweight daily) which cannot accurately be attained when using the syringe, it is recommended that alternative formulations of fenbendazole be used.
Pregnant cats
Pregnant cats can be safely treated with the product but only require a single treatment at the routine adult dose rate. Orally administer 2 syringe graduations per 1 kg bodyweight as a single dose (= 100 mg fenbendazole/kg bodyweight). Each syringe is sufficient to dose up to 9 kg bodyweight as a single dose.
Increased dosing for specific infections:
For the treatment of clinical worm infestations in adult dogs and cats or Giardia spp. infections in dogs and puppies, orally administer 1 syringe graduation per 1 kg bodyweight daily for 3 consecutive days (= 50 mg fenbendazole/kg bodyweight daily for 3 days).
For the control of lungworm Oslerus (Filaroides) osleri in dogs administer 1 syringe graduation per 1 kg bodyweight for 7 consecutive days (= 50 mg fenbendazole/kg bodyweight daily for 7 days). A repeat course of treatment may be required in some cases.
For the control of lungworm Aelurostrongylus abstrusus in cats administer 1 syringe graduation per 1 kg bodyweight for 3 consecutive days (= 50 mg fenbendazole/kg bodyweight daily for 3 days).
To ensure a correct dosage, bodyweight should be determined as accurately as possible.
Overdose
Benzimidazoles have a high margin of safety.
Withdrawal periods
Not applicable.