Pharmacotherapeutic group: anthelmintics. ATCvet code: QP52AX09.
Pharmacodynamic properties
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NI SPC ONLY - Monepantel is an anthelmintic belonging to the amino-acetonitrile derivative (AAD) class of molecules. Monepantel acts on the nematode specific nicotinic acetylcholine receptor sub-unit Hco-MPTL-1. This is the first biological function to be described for the Hco-MPTL-1 receptor and therefore monepantel is effective against nematodes resistant to other anthelmintic classes. |
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ZOLVIX was shown to be effective against strains of gastro-intestinal parasites, listed in section 3.2, resistant to (pro)benzimidazoles, levamisole, morantel, macrocyclic lactones and H. contortus strains resistant to salicylanilides. In addition, the product was shown to be effective against 4th stage larvae of a strain of H. contortus in a laboratory study where a combination of abamectin with derquantel was not effective.
Pharmacokinetic particulars
After oral administration monepantel is readily absorbed and oxidised to a sulfone metabolite. Peak blood concentrations are reached within a day. Afterwards blood concentrations decrease with a half life of about five days. Excretion is mainly via the faeces but also via the urine. Feeding or fasting before or shortly after treatment does not influence efficacy.