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Pharmacological particulars
Pharmacotherapeutic group: Ectoparasiticides for topical use
ATC Vet code: QP53AC04
Pharmacodynamic properties
Permethrin is a neuropoison acting on the axons in the peripheral and central nervous system by interacting with sodium channels in insects. In vitro data obtained using hair from treated animals has demonstrated that the product has the potential to be effective against Culicoides biting midges, although this has not been confirmed by clinical trials.
Pharmacokinetic particulars
Synthetic pyrethroids are generally metabolized in mammals through ester hydrolysis, oxidation and conjugation and there is no tendency to accumulate in tissues.