ATCvet code: QP53AC11. Pharmacotherapeutic group: pyrethroid ectoparasiticide for topical use.
Pharmacodynamic properties: Deltamethrin is a synthetic pyrethroid possessing pesticidal activity. It is one of a large family of pyrethroid esters which have evolved as synthetic analogues of the original insecticidal extracts isolated from powdered pyrethrum flowers. Deltamethrin is an alpha- cyano pyrethroid and is a member of the second generation of pyrethroids in which the overall stability of the molecule is improved with correspondingly increased resistance to photo- and bio-degradation and enhanced insecticidal activity. It is more potently toxic to insects and acarines because of the slower rate of metabolism. The precise mode of insecticidal activity of pyrethroids remains uncertain, but they are potent neurotoxins in insects, causing failure in sensory coordination and disorganised motor activity, hence the 'knock-down' effect. Pyrethroids are metabolised through oxidative and neurotoxic pathways far more rapidly in mammals, so that neurotoxic effects can only occur at dosages which are many orders of magnitude greater than those required for pesticidal activity. Two physiological mechanisms are likely to contribute to deltamethrin-resistance: mutation of the molecular deltamethrin target in some and metabolic enzyme glutathione-S-transferases in some others.
Pharmacokinetic particulars: Environmental properties - Deltamethrin has the potential to adversely affect non-target organisms. Following treatment, deltamethrin is excreted in faeces. Deltamethrin excretion may take place over a period of 2 to 4 weeks. Faeces containing deltamethrin excreted onto pasture by treated animals may reduce the abundance of dung feeding organisms. Deltamethrin is toxic to aquatic organisms and honey bees.