Pharmacotherapeutic group: Dopamine agonists
ATCvet code: QN04BC07
Apomorphine is an aporphine derivative of the dibenzoquinoline class and a synthetic derivative of morphine with no analgesic, opiate or addictive properties.
At lower doses apomorphine induces emesis by stimulation of the dopamine D2-receptors in the chemoreceptor trigger zone (CTZ).
Higher doses of apomorphine may suppress vomiting by stimulation of the µ receptors in the vomiting centre of the brain.
After subcutaneous administration apomorphine is rapidly absorbed.
Apomorphine binds extensively to plasma proteins.
Apomorphine is extensively metabolised by the liver into non-active metabolites. The metabolites and very little unchanged apomorphine (<2%) are excreted via the urine. It is also excreted in breast milk.