metadata toggle
Pharmacological particulars
Pharmacotherapeutic group: Dopamine agonists
ATCvet code: QN04BC07
Pharmacodynamic properties
Apomorphine is an aporphine derivative of the dibenzoquinoline class and a synthetic derivative of morphine with no analgesic, opiate or addictive properties.
At lower doses apomorphine induces emesis by stimulation of the dopamine D2-receptors in the chemoreceptor trigger zone (CTZ).
Higher doses of apomorphine may suppress vomiting by stimulation of the µ receptors in the vomiting centre of the brain.
Pharmacokinetic properties
After subcutaneous administration apomorphine is rapidly absorbed.
Apomorphine binds extensively to plasma proteins.
Apomorphine is extensively metabolised by the liver into non-active metabolites. The metabolites and very little unchanged apomorphine (<2%) are excreted via the urine. It is also excreted in breast milk.