ATCvet code: QG02AD90
Pharmacodynamic properties
Cloprostenol sodium, a (racemic) analogue of prostaglandin F2α (PGF2α), is a very potent luteolytic agent. It causes functional and morphological regression of the corpus luteum (luteolysis) followed by return to oestrus and normal ovulation.
Furthermore, this group of substances has a contractile effect on the smooth muscles (uterus, gastro-intestinal tract, respiratory tract, vascular system).
The veterinary medicinal product does not demonstrate any androgenic, oestrogenic or anti progesterone activity and its effect on pregnancy is due to its luteolytic property.
Unlike other prostaglandin analogues, cloprostenol has no thromboxane A2 activity and does not cause platelet aggregation.
Pharmacokinetic particulars
After intramuscular injection, cloprostenol is rapidly absorbed at peak concentrations of 1.07 ng/mL within 8 minutes. Subsequently, cloprostenol is rapidly eliminated for 1.5 hours followed by a slower elimination phase that results in concentrations below the detection limit between 4 and 6 hours after the administration.