Pharmacotherapeutic group
Antifungals for topical use - imidazole and triazole derivatives.
ATCvet code: QD01AC90
Pharmacodynamic Properties
Enilconazole is a synthetic broad-spectrum antimycotic with a high activity against most of the common dermatophytes and various other fungi and yeasts.
It is a selective inhibitor or ergosterol biosynthesis, an essential component of the cell membrane of fungi and yeasts. This results in irreversible changes which are the origin of the fungi and yeasts. This results in irreversible changes which are the origin of the fungicide effect.
Pharmacokinetic Properties
The systemic availability after topical administration of enilconazole in animals is very low. An extensive first-pass metabolism has been demonstrated after oral administration. Tissue resides are almost non-existent and, relatively, are highest in the liver. Depletion from tissues and plasm occurs with a half-life of about 12 to 16 hours in cattle.
Enilconazole is extensively metabolised and the main excretion routes are urine and faeces. Excretion in the milk from cattle is very limited.