Target species
Chickens
Indications for use, specifying the target species
For active immunisation of one-day-old future layer chicks to reduce mortality, clinical signs and lesions caused by very virulent strains of Marek’s disease virus.
Onset of immunity: 9 days after vaccination.
Duration of immunity: A single vaccination is sufficient to provide protection during the risk period of infection with Marek’s disease virus.
Contraindications
None.
Special warnings for each target species
Vaccinate healthy animals only.
Special precautions for use
Special precautions for use in animals
Spread of the vaccine strain was demonstrated between chickens and may occur from 14 days after vaccination. Vaccinated chickens may excrete the vaccine strain for at least 112 days following vaccination. During this time, the contact of immunosuppressed and unvaccinated chickens with vaccinated chickens should be avoided.
The excreted vaccine strain is safe in non-vaccinated chickens.
Appropriate veterinary and husbandry measures should be taken to avoid spread of the vaccine strain to susceptible species.
Special precautions should be taken to avoid spreading of the vaccine strain to quails and pheasants.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Liquid nitrogen containers and vaccine ampoules should be handled by properly trained personnel only.
Personal protective equipment consisting of protective gloves, spectacles and boots should be worn when handling the veterinary medicinal product, before withdrawing from liquid nitrogen, during the ampoule thawing and opening operations.
Frozen glass ampoules may explode during sudden temperature changes.
Store and use liquid nitrogen in a dry and well-ventilated place only. Inhalation of the liquid nitrogen vapour is dangerous.
Personnel attending vaccinated birds should follow hygiene principles and take particular care in handling litter from vaccinated chickens.
Adverse reactions (frequency and seriousness)
None known
Use during pregnancy, lactation or lay
Laying birds: Do not use in birds in lay.
Interaction with other medicinal products and other forms of interaction
Safety and efficacy data are available which demonstrate that this vaccine can be mixed and administered with Vectormune ND by subcutaneous application.
No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product except the product mentioned above. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.
Amounts to be administered and administration route
Subcutaneous use (preferably under the skin of the neck):
One single injection of 0.2 ml per chick is applied at one day of age.
The vaccine may be injected by automatic syringe. Overview table for recommended dilution possibilities of different presentations:
Cevac MD Rispens No. of ampoules x doses (D) | Solvent presentation (ml) | Volume of one dose (ml) |
1 * 1,000 D | 200 | 0.20 |
1 * 2,000 D | 400 |
2 * 2,000 D | 800 |
1 * 4,000 D | 800 |
4,000 + 1,000 D | 1000 |
3 * 2,000 D | 1200 |
2 * 4,000 D | 1600 |
Overview table for recommended dilution possibilities of different presentations in case of associated use:
No. of ampoules x doses (D) | Solvent presentation (ml) | Volume of one dose (ml) |
Cevac MD Rispens | Vectormune ND |
1 * 1,000 D | 1 * 1,000 D | 200 | 0.20 |
1 * 2,000 D | 1 * 2,000 D | 400 |
2 * 2,000 D | 2 * 2,000 D | 800 |
1 * 4,000 D | 1 * 4,000 D | 800 |
4000 + 1000 D | 4000 + 1000 D | 1000 |
3 * 2,000 D | 3 * 2000 D | 1200 |
2 * 4000 D | 2 * 4000 D | 1600 |
The usual aseptic precautions should be applied to all administration procedures.
Be familiar with all safety and precautionary measures for handling liquid nitrogen in order to prevent personal injury.
Reconstitution of the vaccine:
1. Use Cevac Solvent Poultry for reconstitution. After matching the dose size of the ampoules with the solvent size, quickly remove the exact number of ampoules needed from the liquid nitrogen container.
2. Draw up 2 ml of solvent into a 5 ml syringe. Use minimum 18 gauge needle.
In case of associated use different syringe should be used for each vaccine.
3. Thaw rapidly the contents of the ampoules by gentle agitation in water at 27-39°C.
4. As soon as they are completely thawed, open ampoules holding them at arm length in order to prevent any risk of injury should the ampoule break.
5. Once the ampoule is open, slowly draw up the content into the 5-ml sterile syringe prepared as in point 2.
6. Transfer the thawed suspension into the solvent bag. The reconstituted vaccine prepared as described is mixed by gentle agitation.
7. Withdraw a portion of the diluted vaccine from the solvent bag into the syringe and use it to rinse the ampoule. Inject it gently back into the solvent bag. Repeat once or twice.
8. The reconstituted vaccine prepared as described is mixed by gentle agitation so as to be ready for use.
Repeat the operations in point 2-7 for the appropriate number of ampoules to be thawed.
Use the reconstituted vaccine immediately, slowly mix regularly to ensure uniform suspension of cells and use within a period not exceeding 2 hours.
It should be ensured that the diluted vaccine is mixed regularly in a gentle way during the vaccination session to guarantee that the vaccine remains homogenous and that the correct virus titer is administered during vaccination session.
Overdose (symptoms, emergency procedures, antidotes), if necessary
No symptoms were observed after the administration of a 10-fold overdose of vaccine.
Withdrawal period(s)
Zero days.