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Clinical particulars
Target Species
Cattle, horses, cats and dogs.
Indications for use
A potent saluretic type of diuretic for parenteral administration to cattle, horses, cats and dogs. Dimazon is indicated in the treatment of oedemata associated with cardiac insufficiency, renal dysfunction, trauma and parasitic disease. It is also recommended for the treatment of mammary oedema and limb oedemata.
The product gives rapid onset of diuretic action with increased sodium and water excretion. It is even effective where glomerular filtration is impaired.
Contraindications
Do not use in cases of acute glomerular nephritis renal failure with anuria, electrolyte deficiency disease or overdosage with digitalis.
Do not use concurrently with aminoglycoside antibiotic treatment.
The therapeutic effect may be impaired by increased intake of drinking water. So far as the patient's condition allows, the amount of drinking water should be restricted.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Special warnings for each target species
Clinical experience with dogs indicates that improved results can frequently be achieved by supplementary administration of corticosteroids
Special precautions for use
In pulmonary oedema of cardiac origin, combined therapy with cardiac glycosides is advisable. Only during prolonged treatment is it necessary to monitor potassium balance. Potassium supplements may be necessary.
Operator warnings
Care should be taken to avoid accidental self-injection. If irritation occurs, seek medical attention, showing the product label to a doctor. Following skin/eye contamination, wash/irrigate area with clean, running water immediately. Wash hands after use.
Adverse Reactions
Too rapid injection in dogs may cause staggering and vomiting.
Use during pregnancy or lactation
Can be used during pregnancy and lactation.
Interactions
Potential interactions with other drugs include ototoxicity with aminoglycosides and nephrotoxicity with cephalosporins.
Use in combination with sulphonamide treatment may lead to sulphonamide allergy.
Amounts to be administered and administration route
Species
Dosage mg active/kg bodyweight
ml of 50 mg/ml solution
Administration
Horse
0.5-1.0 i.v.
1-2 ml per 100 kg
1-2 times/day at intervals of 6-8 hours
Cattle
0.5-1.0 i.v.
1-2 ml per 100 kg
At intervals of 12-14 hours
Dog/Cat
2.5-5.0 i.m./ i.v.
0.25-0.5 (per 5kg bodyweight)
First dose 5mg/kg reduced to 1-2mg/kg for maintenance at 6-8 hours intervals.
In severe or refractory cases, the dose may be doubled on a single occasion in the horse or cow.
The product may be administered observing aseptic precautions:
- by intravenous injection only in cattle and horses.
- by intramuscular or intravenous injection only in cats and dogs.
Onset and Duration of Action
Species
Route
Time of onset
Duration
Dog
i.v or i.m
after 10-15 minutes
2-3 hours
Overdose
Doses higher than recommended may cause transitory deafness.
Cardiovascular side effects may be observed in weak and old patients following overdosage.
Withdrawal periods
Cattle:
Meat and offal: 28 days.
Milk: 24 hours.
Horses:
Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human consumption under national horse passport legislation.