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Pharmacological particulars
ATC Vet Code: QP52AF02
Pharmacotherapeutic group
Pyrantel embonate is a broad spectrum anthelmintic with a depolarising neuromuscular blocking action which results in spastic paralysis of the worm, and their expulsion from the intestinal tract.
Pyrantel embonate also inhibits cholinesterases which contributes to its neuromuscular effects. Pyrantel embonate is poorly absorbed from the gastrointestinal tract, making it suitable for use as an intestinal anthelmintic. The small amount of pyrantel embonate which is absorbed is quickly metabolised with little being excreted intact.
Pyrantel embonate has a broad spectrum of activity, including activity against:
Large strongyles: Stronglylus vulgaris, S. edentatus, S. equinus.
Small strongyles: Trichonema spp. (Cyathostomes), Triodontophorus spp.
Pinworms: Oxyuris equi, Probstmayria vivipara.
Large roundworms: Parascaris equorum.
Tape worms: Anoplocephala perfoliata.