Target species
Cats.
Indications for use, specifying the target species
Treatment of mixed infections by immature and adult cestodes and nematodes of the following species:
- Cestodes:
Dipylidium caninum
Taenia spp.
Echinococcus multilocularis
- Nematodes:
Ancylostoma tubaeforme
Toxocara cati
Prevention of heartworm disease (Dirofilaria immitis) if concomitant treatment against cestodes is indicated.
Contraindications
MilbeVet 4 mg/10 mg: Do not use in cats of less than 6 weeks of age and/or weighing less than 0.5 kg.
MilbeVet 16 mg/40 mg: Do not use in cats weighing less than 2 kg.
Special warnings
In order to develop an effective worm control programme local epidemiological information and the risk of exposure of the cat should be taken into account.
It is recommended to treat all the animals living in the same household concomitantly.
When infection with the cestode D. caninum has been confirmed, concomitant treatment against intermediate hosts, such as fleas and lice, should be discussed with a veterinarian to prevent re-infection.
Special precautions for use
Special precautions for use in animals
As per good veterinary practice, animals should be weighed to ensure accurate dosing.
Ensure cats and kittens weighing between 0.5 kg and ≤2 kg receive the appropriate tablet strength (4 mg MBO/10 mg praziquantel) and the appropriate dose (1/2 or 1 tablet) for the corresponding weight band (1/2 tablet for cats weighing 0.5 to 1 kg; 1 tablet for cats weighing >1 to 2 kg – 1 tablet).
Echinococcosis represents a hazard for humans. In case of Echinococcosis, specific guidelines on the treatment and follow up and on the safeguard of persons have to be followed. Experts or institutes of parasitology should be consulted.
No studies have been performed with severely debilitated cats or individuals with seriously compromised kidney or liver function. The product is not recommended for such animals or only according to a benefit/risk assessment by the responsible veterinarian.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Wash hands after use.
In the event of accidental ingestion of the tablets, particularly by a child, seek medical advice immediately and show the package leaflet or the label to the physician.
Special precautions for the protection of the environment
Not applicable.
Adverse reactions (frequency and seriousness)
Very rare (<1 animal / 10,000 animals treated, including isolated reports) | Gastrointestinal signs (such as Diarrhoea, Emesis)1 Hypersensitivity reactions1 Neurological signs (such as Ataxia, Muscle tremors) 1 Systemic signs (such as Lethargy)1 |
1especially in young cats
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Use during pregnancy, lactation or lay
Can be used in breeding cats including pregnant and lactating queens.
Interaction with other medicinal products and other forms of interaction
The concurrent use of the veterinary medicinal product with selamectin is well tolerated. No interactions were observed when the recommended dose of the macrocyclic lactone selamectin was administered during treatment with the veterinary medicinal product at the recommended dose.
Although not recommended, the concomitant use of the veterinary medicinal product with a spot on containing moxidectin and imidacloprid at recommended dose rates following a single application was well tolerated in one laboratory study in 10 kittens.
The safety and efficacy of the concurrent use have not been investigated in field studies. In the absence of further studies, caution should be taken in the case of concurrent use of the product with any other macrocyclic lactone. Also, no such studies have been performed with reproducing animals.
Amounts to be administered and administration route
Oral use.
To ensure a correct dosage, body weight should be determined as accurately as possible.
Minimum recommended dose rate: 2 mg of milbemycin oxime and 5 mg of praziquantel per kg. The veterinary medicinal product should be administered with or after some food. Doing so ensures optimum protection against heartworm disease.
Depending on the bodyweight of the cat, the practical dosing is as follows:
Weight | Tablets |
| MilbeVet 4 mg/10 mg film-coated tablets for small cats and kittens | MilbeVet 16 mg/40 mg film-coated tablets for cats |
0.5 - 1 kg | 1/2 tablet | |
> 1 - 2 kg | 1 tablet | |
2 - 4 kg | | 1/2 tablet |
> 4 - 8 kg | | 1 tablet |
> 8 - 12 kg | | 11/2 tablets |
The veterinary medicinal product can be inserted into a programme for prevention of heartworm disease if at the same time treatment against tapeworms is indicated. The duration of heartworm prevention is one month. For regular prevention of heartworm disease the use of a monosubstance is preferred.
Overdose (symptoms, emergency procedures, antidotes), if necessary
In case of overdose, in addition to signs observed at the recommended dose (see section Adverse reactions), drooling was observed. This sign will usually disappear spontaneously within a day.
Withdrawal period(s)
Not applicable.