Target species
For cats and pet rabbits
For Small Dogs see datasheet: Advantage Spot-On Solution for Dogs
Indications for use, specifying the target species
For the prevention and treatment of flea infestations on cats.
For the treatment of flea infestations on pet rabbits.
Fleas are killed within one day following treatment. One treatment prevents further flea infestation for three to four weeks on cats and up to one week on pet rabbits. The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD) in cats where this has been previously diagnosed by a veterinary surgeon.
Contraindications
Do not treat unweaned kittens of less than 8 weeks of age.
Do not use on pet rabbits of less than 10 weeks of age.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Special warnings for each target species
There are no special warnings required for the target species.
Special precautions for use
i. Special precautions for use in animals
Care should be taken to avoid the contents of the tube coming into contact with the eyes or mouth of the user or recipient animal.
Do not allow recently treated animals to groom each other.
Any collar should be removed prior to application of the product. Prior to re-fitting the collar, the treated area should be visually assessed to ensure it is dry.
For external use only.
ii. Special precautions to be taken by the person administering the medicinal product to animals
Wash hands thoroughly after use.
Wash off any skin contamination with soap and water.
After application do not stroke or groom animals until the application site is dry (typically within an hour or so).
People with known hypersensitivity to Imidacloprid should avoid contact with the veterinary medicinal product.
This product contains benzyl alcohol and may cause skin sensitisation or transient skin reactions (for example allergy, irritation, tingling).
Avoid contact between the product and the skin, eyes or mouth. Do not massage the application site.
If the product gets into eyes accidentally, the eyes should be thoroughly flushed with water. If skin or eye irritation persists, obtain medical attention.
If the product is accidentally swallowed, obtain medical attention immediately.
Do not eat, drink or smoke during application.
iii. Other precautions
The solvent in this product may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials.
Imidacloprid is toxic to aquatic organisms. To avoid adverse effects on aquatic organisms, treated dogs should not be allowed to enter surface water for 48 hours after treatment.
Adverse reactions (frequency and seriousness)
The product is bitter tasting and salivation may occasionally occur if the animal licks the application site immediately after treatment. This is not a sign of intoxication and disappears within a few minutes without treatment (see also section, 'Amount to be administered and administration route').
On very rare occasions skin reactions such as hair loss, redness, itching and skin lesions may occur. Agitation has also been reported. Excessive salivation and nervous signs such as incoordination, tremors and depression have been reported exceptionally in cats.
Oral ingestion may result in other gastrointestinal signs (vomiting and diarrhoea), which have been observed very rarely based on post-marketing data.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports)
Use during pregnancy, lactation or lay
No reproductive toxic effects have been observed in rats and no primary embryotoxic or teratogenic toxic effects have been observed during the studies on rats and rabbits. Studies on pregnant and lactating bitches, queens and does together with their offspring are limited. Evidence so far suggests that no adverse effects are to be expected in these animals.
Interaction with other medicinal products and other forms of interaction
No incompatibility has been observed between this product at twice the recommended dose and the following commonly used veterinary products: lufenuron, febantel, pyrantel and praziquantel (dogs) and lufenuron, pyrantel and praziquantel (cats). The compatibility of the product was also demonstrated with a wide range of routine treatments under field conditions including vaccination.
Amount(s) to be administered and administration route
Dosage and Treatment Schedule
Cat & Pet Rabbit (kg body weight) | Product | Number of Tubes | mg/kg bw |
Less than 4 kg bodyweight | Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs and Pet Rabbits | 1 x 0.4 ml | Minimum of 10 |
4 kg and greater | Advantage 80 mg Spot-On Solution for Large Cats & Pet Rabbits | 1 x 0.8 ml | Maximum of 20 |
Treatment should be repeated after 4 weeks. Treatment of nursing queens controls flea infestations on both dam and offspring.
Fleas are killed within one day following treatment. One treatment prevents further flea infestation on cats for 3-4 weeks and on rabbits for up to one week. Should re-treatment become necessary earlier than 4 weeks, do not re-treat more frequently than weekly.
Re-infestation from emergence of new fleas in the environment may continue to occur for six weeks or longer after treatment is initiated. More than one treatment may therefore be required, depending on the level of fleas in the environment. To aid reduction in environmental challenge, the additional use of a suitable environmental treatment against adult fleas and their developing stages is recommended. In order to reduce further the environmental challenge, it is recommended that all dogs, cats and rabbits in the household are treated.
The product remains effective if the animal becomes wet, for example after exposure to heavy rain or after swimming. However, re-treatment may become necessary, depending on the presence of fleas in the environment. In these cases do not treat more frequently than once weekly.
Method of Administration
Remove one tube from the package. Hold tube in an upright position, twist and pull off cap. Use reversed cap to twist and remove seal from tube.
Administration to the Cat
Part the hair on the cat's neck at the base of the skull until the skin is visible.
Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin.
Administration to the Rabbit
Part the hair on the rabbit’s neck at the base of the skull until the skin is visible.
Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin.
All Species
Correct application will minimise the opportunity for the animal to lick off the product.
Apply only to undamaged skin. Do not allow recently treated animals to groom each other.
Overdose (symptoms, emergency procedures, antidotes), if necessary
In cats, no adverse clinical signs were produced using doses of five times the therapeutic level for eight consecutive weeks.
In rabbits, no adverse clinical signs were seen using doses of up to 45 mg/kg body weight (4 times the therapeutic level) weekly for 4 consecutive weeks.
Poisoning following inadvertent oral uptake in either man or animals is unlikely. In this event, treatment should be symptomatic. There is no known specific antidote but administration of activated charcoal may be beneficial.
Withdrawal period(s)
Not applicable as the veterinary medicinal product is not indicated for the treatment of food producing animals.
Do not use in rabbits intended for human consumption.