Target species
Dogs.
Indications for use
In adult dogs:
For the treatment of mixed infections with roundworms, hookworms, whipworms, and tapeworms of the following species:
Roundworms (Nematodes):
Ascarids (adult and late immature forms): Toxocara canis, Toxascaris leonina.
Hookworms (adults): Uncinaria stenocephala, Ancylostoma caninum.
Whipworms (adults): Trichuris vulpis.
Tapeworms (Cestodes):
Adult and immature forms of: Echinococcus species (E. granulosus, E. multilocularis), Taenia species (T. hydatigena, T. pisiformis, T. taeniformis), Dipylidium caninum.
Contraindications
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Do not use simultaneously with piperazine compounds as piperazine may block the action of pyrantel embonate contained in this product. Other worming products may contain piperazine.
Do not use simultaneously with other deworming products without veterinary advice.
Do not exceed the stated dose.
Special warnings for each target species
Fleas serve as intermediate hosts for one common type of tapeworm – Dipylidium caninum. Tapeworm infestation is certain to reoccur unless control of intermediate hosts such as fleas, mice, etc. is undertaken.
Dogs should also be prevented from scavenging or hunting as part of measures to prevent tapeworm reinfestation.
If your dog receives other veterinary medicinal products, check with a veterinary surgeon or pharmacist before using this product.
Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.
Special precautions for use
Special precautions for use in animals
Do not exceed the stated dose, especially when treating pregnant bitches.
To ensure administration of a correct dose, body weight should be determined as accurately as possible.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
In case of accidental ingestion, seek medical advice and show the package leaflet to the physician.
In the interests of good hygiene, persons administering the tablets either directly to the dog, or by adding them to the dog's food, should wash their hands afterwards.
Other precautions
Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable disease to the World Organisation for Animal Health (OIE), specific guidelines on the treatment and follow-up, and on the safeguard of persons, need to be obtained from the relevant competent authority.
Adverse reactions (frequency and seriousness)
In very rare cases mild and transient digestive tract disorders such as vomiting and/or diarrhoea may occur. In individual cases these signs can be accompanied by nonspecific signs such as lethargy, anorexia, or hyperactivity.
The frequency of adverse reactions is defined using the following convention:
- Very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- Common (more than 1 but less than 10 animals in 100 animals treated)
- Uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- Rare (more than 1 but less than 10 animals in 10,000 animals treated)
- Very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Use during pregnancy, lactation or lay
Consult a veterinary surgeon before treating pregnant animals.
Teratogenic effects attributed to high doses of febantel have been reported in sheep and rats. No studies have been performed in dogs during early pregnancy. Use of the product during pregnancy should be in accordance with a benefit risk assessment by the responsible veterinarian. It is recommended that the product is not used in dogs during the first 4 weeks of pregnancy.
The product may be used in lactating bitches from two weeks after giving birth (see Section 'Amounts to be administered and administration route' below).
Interaction with other medicinal products and other forms of interaction
Do not use simultaneously with piperazine compounds as the anthelmintic effects of pyrantel and piperazine may be antagonized (see section 'Contraindications' above).
Concurrent use with other cholinergic compounds (e.g. neostigmine, propoxur, and bethanechol) can lead to toxicity.
Amounts to be administered and administration route
For oral administration only.
To ensure administration of a correct dose, body weight should be determined as accurately as possible.
Dosage:
1 tablet per 35 kg bodyweight.
This is equivalent to 15 mg febantel, 14.4 mg pyrantel embonate and 5 mg praziquantel per kilo bodyweight.
It is important to follow the treatment recommendations as presented here. Do not deviate from the recommendations without the advice of your veterinary surgeon.
Dosage table:
Bodyweight (kg) | Tablets |
17.5 | ½ |
>17.5-35.0 | 1 |
>35.0-52.5 | 1½ |
>52.5-70 | 2 |
Administration and duration of treatment
Not for use in dogs weighing less than 17.5 kg.
The tablets can be given directly to the dog or disguised in food. No starvation is needed before or after treatment.
For routine worm control adult dogs should be treated with a single dose every 3 months.
For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every two weeks until weaning.
In case of suspected heavy roundworm infestation, please contact your veterinary surgeon for diagnosis and treatment recommendations.
If there is a risk of re-infestation (see section 'Special warnings for each target species'), the advice of a veterinarian should be sought regarding the need for and the frequency of repeat administration.
Overdose (symptoms, emergency procedures, antidotes), if necessary
The combination of praziquantel, pyrantel embonate and febantel is well tolerated in dogs. In safety studies, a single dose of 5 times the recommended dose or greater gave rise to occasional vomiting.
Withdrawal period(s)
Not applicable.