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Contra-indications, warnings, etc
Do not use simultaneously with piperazine compounds as piperazine may block the action of pyrantel embonate contained in this product. Other worming products may contain piperazine.
Do not use simultaneously with other deworming products without veterinary advice.
Do not use in animals with a known sensitivity to the active ingredients or to any of the excipients.
Special warnings for each target species
Fleas serve as intermediate hosts for one common type of tapeworm – Dipylidium caninum. Tapeworm infestation is certain to reoccur unless control of intermediate hosts such as fleas, mice, etc. is undertaken. Tapeworm infestation is unlikely in pups less than 6 weeks of age. Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.
Special precautions for use
i) Special precautions for use in animals
Do not exceed the stated dose, especially when treating pregnant bitches.
ii) Special precautions to be taken by the person administering the veterinary medicinal product to animals
In case of accidental ingestion, seek medical advice and show the package leaflet to the physician. In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog’s food, should wash their hands afterwards. Echinococcosis represents a hazard for humans. As echinococcosis is a notifiable disease to the World Organisation for Animal Health (OIE), specific guidelines on the treatment and follow-up, and on the safeguard of persons, need to be obtained from the relevant competent authority.
Use during pregnancy, lactation or lay
Consult a veterinary surgeon before treating pregnant animals. Teratogenic effects attributed to high doses of febantel have been reported in sheep and rats. No studies have been performed in dogs during early pregnancy. Use of the product during pregnancy should be in accordance with a benefit risk assessment by the responsible veterinarian. It is recommended that the product is not used in dogs during the first 4 weeks of pregnancy.
The product may be used in lactating bitches from two weeks after giving birth.
Interaction with other medicinal products and other forms of interaction
Do not use simultaneously with piperazine compounds. Concurrent use with other cholinergic compounds can lead to toxicity.
Withdrawal period
Not applicable
Overdose (symptoms, emergency procedures, antidotes),
if necessary The combination of praziquantel, pyrantel embonate and febantel is well tolerated in dogs. In safety studies, a single dose of 5 times the ecommended dose or greater gave rise to occasional vomiting.
Adverse reactions (frequency and seriousness)
In very rare cases slight and transient digestive tract disorders such as vomiting and /or diarrhoea may occur. In individual cases these signs can be accompanied by nonspecific signs such as lethargy, anorexia or hyperactivity.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports)