Pharmacotherapeutic group: Musculo-skeletal system, other drugs for disorders of the musculo-skeletal system, equine stem cells.
ATC Vet Code: QM09AX90
Pharmacodynamic properties
Mesenchymal stem cells have immunomodulatory and anti-inflammatory properties that may attributed to their paracrine activity, e.g. prostaglandin (PGE2) secretion, and can possess tissue regenerative properties.
These pharmacodynamic properties may be also relevant for equine umbilical cord derived MSCs (EUC-MSCs) but have not been demonstrated in proprietary studies conducted with the product. The potential of EUC-MSCs to secrete PGE2 with and without stimulation by synovial fluid has been demonstrated in studies in vitro.
Pharmacokinetic particulars
To what extent EUC-MSCs from this product persist after intra articular administration to dogs is not known as no proprietary biodistribution studies have been conducted with DogStem.