Target species
Chicken embryonated eggs.
Indications for use, specifying the target species
For the active immunisation of chickens to reduce clinical signs, intestinal lesions and oocysts output associated with coccidiosis caused by Eimeria acervulina, Eimeria maxima, Eimeria praecox and Eimeria tenella.
Onset of immunity: 21 days of age.
Duration of immunity: 63 days of age in an environment that permits oocysts recycling.
Contraindications
None.
Special warnings for each target species
This product is intended for the vaccination of short-lived chickens only. No data are available on protection of longer-lived birds such as future layers/breeders. The vaccine will not protect species other than chickens against coccidiosis. Vaccinate healthy embryos only.
Special precautions for use
Special precautions for use in animals
Chickens must be strictly floor-reared in the first 3 weeks after vaccination. In order to reduce field infections, it is recommended that all litter should be removed and facilities and related equipment in contact with vaccinated chickens should be cleaned between production cycles.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Wash and disinfect hands and equipment after use.
Adverse reactions (frequency and seriousness)
None known.
Use during pregnancy, lactation or lay
Not applicable.
Interaction with other medicinal products and other forms of interaction
Safety and efficacy data are available which demonstrate that this vaccine can be mixed with GUMBOHATCH prior to use and administered simultaneously in ovo. The product information of GUMBOHATCH should be consulted before administration of the mixed products.
The mixed administration of GUMBOHATCH and EVANOVO should only be used when vaccinating 18-day-old embryonated eggs.
For mixed use, the onset and duration of immunity of the Eimeria species included in the EVANOVO vaccine have been demonstrated to be equivalent to those determined for EVANOVO when used alone.
No information is available on the safety and efficacy of this immunological veterinary medicinal product when used with any other veterinary medicinal product except the product mentioned above. A decision to use this immunological veterinary medicinal product before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.
No anticoccidial substances or other agents having anticoccidial activity via feed or water should be used for at least 3 weeks following the hatching of eggs vaccinated with this product otherwise the correct replication of the vaccine oocysts, and consequently the development of a solid immunity, could be hindered. Additionally, the duration of immunity depends on an environment that permits recycling of oocysts, therefore a decision to use any anticoccidial substances in the period after 3 weeks of age should be made taking into account the potential negative impact on the duration of immunity of this product.
Amounts to be administered and administration route
In ovo administration.
Vaccination schedule:
Administer one single injection of 0.05 ml or 0.1 ml of the diluted vaccine suspension into each chicken egg at 18 days of embryonation.
Method of administration:
An automated egg injection machine can be used. In ovo equipment should be previously calibrated to ensure that a 0.05 ml or 0.1 ml dose is applied. The instructions for the calibration and use of the equipment should be strictly followed, in order to deliver the appropriate dose in the amnion of the embryonated egg.
For the dilution and administration of the vaccine, use sterile equipment free from any residues of chemical disinfectants.
Prepare the required volume of the vaccine as per the examples provided in the tables below, showing different dilution possibilities, according to different presentations:
Dilutions for in ovo administration (0.05 ml per dose):
Number and content of vaccine vials | HIPRAHATCH solvent volume to be used | Volume of solvent to be withdrawn before vaccine dilution |
4 x 1,000 doses | 200 ml | 24 ml |
2 x 2,000 doses | 200 ml | 24 ml |
4 x 2,000 doses | 400 ml | 48 ml |
1 x 4,000 doses | 200 ml | 24 ml |
2 x 4,000 doses | 400 ml | 48 ml |
4 x 4,000 doses | 800 ml | 96 ml |
5 x 4,000 doses | 1,000 ml | 120 ml |
2 x 5,000 doses | 500 ml | 60 ml |
4 x 5,000 doses | 1,000 ml | 120 ml |
1 x 8,000 doses | 400 ml | 48 ml |
2 x 8,000 doses | 800 ml | 96 ml |
1 x 10,000 doses | 500 ml | 60 ml |
2 x 10,000 doses | 1,000 ml | 120 ml |
Dilutions for in ovo administration (0.1 ml per dose):
Number and content of vaccine vials | HIPRAHATCH solvent volume to be used | Volume of solvent to be withdrawn before vaccine dilution |
2 x 1,000 doses | 200 ml | 12 ml |
4 x 1,000 doses | 400 ml | 24 ml |
1 x 2,000 doses | 200 ml | 12 ml |
2 x 2,000 doses | 400 ml | 24 ml |
4 x 2,000 doses | 800 ml | 48 ml |
1 x 4,000 doses | 400 ml | 24 ml |
2 x 4,000 doses | 800 ml | 48 ml |
1 x 5,000 doses | 500 ml | 30 ml |
2 x 5,000 doses | 1,000 ml | 60 ml |
1 x 8,000 doses | 800 ml | 48 ml |
1 x 10,000 doses | 1,000 ml | 60 ml |
Dilution of the vaccine:
1. Withdraw from the HIPRAHATCH solvent bag the same millilitres that are going to be injected of vaccine (EVANOVO), as stated in the example tables above.
2. Shake the vaccine vial/s and inject the content of it/them into the HIPRAHATCH solvent bag. Mix the contents of the bag by gentle agitation until the contents are completely diluted.
3. The diluted vaccine is a white suspension, which should be used within 10 hours after dilution. Mix the bag by gentle agitation every 30 minutes during vaccination. The vaccine must be injected into the amniotic sac of 18-day-old embryonated chicken eggs.
For simultaneous use with GUMBOHATCH, the mixed administration of EVANOVO and GUMBOHATCH should only be used when vaccinating in ovo 18-day-old embryonated eggs.
The following instructions should be used:
1.1 Taking into account the HIPRAHATCH solvent bag volume, prepare the EVANOVO vaccine as described above.
1.2 Once the EVANOVO vaccine has been prepared, consider the bag volume to prepare enough GUMBOHATCH doses for the bag volume.
1.3 In each GUMBOHATCH vial to be used, insert 4 ml of the EVANOVO diluted vaccinal suspension prepared in section 1.1.
1.4 Once the lyophilized tablet is properly resuspended, introduce the volumes of the different GUMBOHATCH vials into the vaccinal bag.
1.5 Homogenize by moving the bag volume with the hands until having an even homogenate solution.
1.6 Vaccinate using the vaccinal bag with the mixed vaccines within a period of 2 hours via in ovo. Mix the bag by gentle agitation every 30 minutes during vaccination.
Prepare the required volume of each vaccine as per the examples provided in the table below, showing different mixing possibilities, according to different presentations
for in ovo administration (0.05 ml per dose):
GUMBOHATCH (Number and content of vaccine vials) | EVANOVO (Number and content of vaccine vials) | HIPRAHATCH solvent volume to be used |
4 x 1,000 doses | 4 x 1,000 doses | 200 ml |
2 x 2,000 doses | 2 x 2,000 doses | 200 ml |
4 x 2,000 doses | 4 x 2,000 doses | 400 ml |
1 x 4,000 doses | 1 x 4,000 doses | 200 ml |
2 x 4,000 doses | 4 x 2,000 doses | 400 ml |
2 x 4,000 doses | 2 x 4,000 doses | 400 ml |
4 x 4,000 doses | 4 x 4,000 doses | 800 ml |
2 x 5,000 doses | 2 x 5,000 doses | 500 ml |
8 x 2,500 doses | 4 x 5,000 doses | 1,000 ml |
2 x 4,000 doses | 1 x 8,000 doses | 400 ml |
1 x 8,000 doses | 1 x 8,000 doses | 400 ml |
4 x 4,000 doses | 2 x 8,000 doses | 800 ml |
2 x 8,000 doses | 2 x 8,000 doses | 800 ml |
4 x 2,500 doses | 1 x 10,000 doses | 500 ml |
1 x 10,000 doses | 1 x 10,000 doses | 500 ml |
5 x 4,000 doses | 2 x 10,000 doses | 1,000 ml |
4 x 5,000 doses | 2 x 10,000 doses | 1,000 ml |
2 x 10,000 doses | 2 x 10,000 doses | 1,000 ml |
Overdose (symptoms, emergency procedures, antidotes), if necessary
None.
Withdrawal period(s)
Zero days.