The veterinary medicinal product contains the active substance hydrocortisone aceponate.

Hydrocortisone aceponate (HCA) belongs to the diester class of the glucocorticosteroids with a potent intrinsic glucocorticoid activity. The product relieves both inflammation and pruritus which leads to an improvement of clinical signs of otitis externa and a reduction of bacteria and yeast overgrowth.

HCA is a lipophilic component ensuring an enhanced penetration into the skin associated with a low plasma availability and systemic exposure. After topical or auricular administration, HCA accumulates slightly in the dog’s skin, in the dermis and hypodermis of the dog’s ear canal. HCA is transformed inside the skin structures. This transformation is responsible for the potency of the therapeutic class. In laboratory animals, HCA is eliminated the same way as hydrocortisone (other name for endogenous cortisol) through urine and faeces.