Target species
Dogs
Special warnings
See sections Contraindications and Special Precautions for Use.
Special precautions for use
Special precautions for safe use in the target species:
Use in aged dogs may involve additional risk. If such a use cannot be avoided, dogs may require a reduced dosage and careful clinical management.
Avoid use in any dehydrated, hypovolaemic or hypotensive dog, as there is a potential risk of increased renal toxicity.
Concurrent administration of potential nephrotoxic drugs should be avoided.
NSAIDs can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infection, appropriate concurrent antimicrobial therapy should be instigated.
As with other NSAIDs, photodermatitis during treatment with carprofen has been observed in laboratory animals and in humans. These skin reactions have never been observed in dogs.
Do not administer other NSAIDs concurrently or within 24 hours of each other.
Due to the good palatability of the tablet, they should be stored in a safe place out of the reach of animals. Intake of dose exceeding the recommended number of tablets may lead to severe adverse effects. If this is the case, seek veterinary assistance immediately.
Special precautions to be taken by the person administering the veterinary medicinal product to animals:
In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
Wash hands after handling the veterinary medicinal product.
Special precautions for the protection of the environment:
Not applicable.
Adverse events
Dogs
Rare (1 to 10 animals / 10,000 animals treated): | Renal disorder1 Hepatic disorder 1,3 |
Very rare (<1 animal / 10,000 animals treated, including isolated reports): | Vomiting2, Soft stool2 /Diarrhoea2, Blood in faeces2 Appetite loss2, Lethargy2 |
1As with other NSAIDs
2 Typical undesirable effects associated with NSAIDs, these adverse reactions generally occur within the first treatment week and are in most cases transient and
disappear following termination of the treatment but in very rare cases may be serious or fatal.
3 Idiosyncratic effects
If adverse reactions occur, use of the product should be stopped and the advice of a veterinarian should be sought.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Interaction with other medicinal products and other forms of interaction
Carprofen is highly bound to plasma proteins and compete with other highly bound drugs, which can increase their respective toxic effects.
Do not use this veterinary medicinal drug concurrently with other NSAIDs or with glucocorticoids.
Concurrent administration of potentially nephrotoxic drugs (e.g. aminogylcoside antibiotics) should be avoided.
Refer also to Special precautions for use.
Administration routes and dosage
Oral use.
4 mg carprofen per kg bodyweight per day.
An initial dose of 4 mg carprofen per kg bodyweight per day given as a single daily dose. The analgesic effect from each dose persists for at least 12 hours.
The daily dose may be reduced, subject to clinical response.
Duration of treatment will be dependant upon the response seen. Long-term treatment should be under regular veterinary supervision.
To extend analgesic and anti-inflammatory cover post-operatively parenteral pre-operative treatment with an injectable carprofen may be followed with carprofen tablets at 4 mg/kg/day for 5 days.
Do not exceed the stated dose. To ensure a correct dosage, body weight should be determined as accurately as possible.
The breakability method is the following: Put the tablet on a plain surface, with its scored side facing the surface (convex face up). With the tip of forefinger, exert a slight vertical pressure on the middle of the tablet to break it in its width into halves. In order to obtain quarters, then exert a slight pressure on the middle of one half with forefinger to break it in its length.
The tablet is divisible and can be used as follows:
Number of tablets per day | Dog weight (kg) |
¼ | > 3 - < 6 |
½ | ≥ 6 - < 9 |
¾ | ≥ 9 - < 12.5 |
1 | ≥ 12.5 - < 15.5 |
1 ¼ | ≥ 15.5 - < 18.5 |
1 ½ | ≥ 18.5 - < 21.5 |
1 ¾ | ≥ 21.5 - < 25 |
2 | ≥ 25 - < 28 |
2 ¼ | ≥ 28 - < 31 |
2 ¾ | ≥ 34 - < 37 |
3 | ≥ 37 - < 40 |
3 ¼ | ≥ 40 - < 43 |
3 ½ | ≥ 43 - < 45 |
Symptoms of overdose (and where applicable, emergency procedures, and antidotes)
Bibliographic data report that carprofen is well tolerated in dogs at twice the recommended dosage for 42 days.
Doses up to 3 times the recommended dose are reported to be without adverse effects.
There is no specific antidote to carprofen but general supportive therapy as applied to clinical overdose with NSAIDs should be applied.
Special restrictions for use and special conditions for use, including restrictions on the use of antimicrobial and antiparasitic veterinary medicinal products in order to limit the risk of development of resistance
Not applicable
Withdrawal periods
Not applicable.