Amount(s) to be administered and administration route
In drinking water use.
The recommended dose is 10 mg florfenicol per kg bodyweight per day (equivalent to 5 mL of the product/100 kg bw) for 5 consecutive days.
To ensure a correct dosage body weight should be determined as accurately as possible. In order to avoid under and over-dosing, treated animals should be divided into groups of similar bodyweight and the dose should be calculated for each group individually.
Medicated water intake depends on many factors including the clinical condition of the animal as well as local conditions such as ambient temperature and humidity.
All animals to be treated should have sufficient access to the water supply system to ensure adequate consumption of the medicated drinking water. In order to ensure consumption of the medicated water, animals should not have access to other water supplies whilst being treated. If, however, it is not possible to obtain a sufficient intake of medicated water, the animals should be treated parenterally.
The appropriate quantity of medicated water should be prepared based on the daily water consumption. In order to obtain the correct dosage, the water uptake has to be monitored and the concentration of florfenicol has to be adjusted accordingly.
Based on the recommended dose, and the number and weight of the animals to be treated, the exact daily concentration of the veterinary product should be calculated according to the following formula:
X mL veterinary medicinal product/kg body weight/day | x Average body weight (kg) of animals to be treated | = X mL veterinary product per litre drinking water |
Average daily water consumption (litre) per animal | |
If a weighing scale is used the required volume can be converted based considering the following calculation:
quantity in g of product required per day = number of ml of product required per day x 1.075.
Accuracy of the dosing device should be thoroughly checked.
Shake the bottle vigorously for 60 seconds before use. The product should be added to the water.
Prepare the solution with fresh potable water.
For water tanks:
The maximal solubility is reached at concentrations of 2 mL/L (0.4 g of florfenicol/L), 2.5 mL/L (0.5 g of florfenicol/L) and 3 ml/L (0.6 g of florfenicol/L) at respectively 4°C, 10°C and 20°C. Solutions should be checked visually for complete dissolution.
To treat pigs drinking 10% of their bodyweight, at the dose of 10 mg/kg, add the veterinary medicinal product to the drinking water in the tank.
Use 1 L of product for every 2000 L of water. This corresponds to a concentration of 0.10 g florfenicol /L in the drinking water. Mix thoroughly, to achieve full dissolution the solution should be stirred vigorously using a manual whisk for 10 minutes. When using a magnetic stirrer at 100 rpm, the mixing time is of 5 minutes.
For dosing pumps:
The veterinary medicinal product can only be used at a concentration of 50 mL/L i.e. 10 g of florfenicol per litre of water of stock solution.
To treat pigs drinking 10% of their bodyweight, at the dose of 10 mg/kg, add the veterinary medicinal product to the water in the reservoir of the dosing pump.
Add 1 L of product to 20 L of unmedicated water. This corresponds to a concentration of 10 g/L in the stock solution.
Mix thoroughly using a manual whisk for 10 minutes or automatic stirring device operating 840 rpm for 5 min until a homogeneous white milky suspension is obtained. Set the dosing pump on 1 % and turn on the dosing pump.
Medicated drinking water should be replaced every 24 hours.
After the end of the medication period the water supply system should be cleaned appropriately to avoid intake of sub-therapeutic amounts of the active substance .
Overdose (symptoms, emergency procedures, antidotes), if necessary
In case of overdosing, a decrease in weight gain, food and water consumption, peri-anal erythema and oedema and modification of some haematological and biochemical parameters indicative of dehydration may be observed.
Withdrawal period(s)
Meat and offal: 20 days