Target species
Cows
Indications for use
For the treatment of subacute and chronic endometritis in cows (at least 14 days after parturition) caused by bacteria susceptible to cefapirin.
Contraindications
Do not use in in animals with known hypersensitivity to cephalosporins or to any of the excipients.
Special warnings for each target species
None.
Special precautions for use
Special precautions for use in animals
Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria. Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to cefapirin and may decrease the effectiveness of the treatment.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Penicillin and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillin may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances are occasionally serious.
1. Do not handle this product if you know you are sensitised or if you have been advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all recommended precautions.
3. If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention.
Gloves should be worn in order to avoid skin contact during preparation and administration of the product.
Accidental spillage on the skin should be washed off immediately with soap and water.
Wash hands after use.
Adverse reactions (frequency and seriousness)
Allergic reactions have been observed in very rare cases. The frequency of adverse reactions is defined using the following convention:
•very common (more than 1 in 10 animals displaying adverse reaction(s))
•common (more than 1 but less than 10 animals in 100 animals)
•uncommon (more than 1 but less than 10 animals in 1,000 animals)
•rare (more than 1 but less than 10 animals in 10,000 animals)
•very rare (less than 1 animal in 10,000 animals, including isolated reports). 4.7
Use during pregnancy, lactation or lay Pregnancy and lactation:
The product is not recommended for use during pregnancy but can be used during lactation.
Interaction with other medicinal products and other forms of interaction
Not to be administered concurrently with other intrauterine antibiotic preparations.
Amounts to be administered and administration route
The contents of one syringe should be introduced into the lumen of the uterus using the disposable catheter provided as follows:
1. The product may settle but can be re-suspended by gentle shaking into a homogeneous suspension.
2. Fix the syringe to the catheter.
3. Take the cervix of the uterus into one gloved hand introduced into the rectum.
4. Introduce the catheter through the cervix into the lumen of the uterus, by gentle oscillating movements of the cervix.
5. Inject the contents of the syringe into the uterus.
Depending on the response, a second treatment 7-14 days later may be required in some cases if clinical signs persist.
In animals that have been inseminated the product may be used one day after insemination. In cases of pyometra, pre-treatment with prostaglandin is recommended in order to induce luteolysis and remove debris from the uterine cavity.
Overdose (symptoms, emergency procedures, antidotes), if necessary
Product supplied as a single dose syringe therefore overdose unlikely to occur.
Withdrawal period(s)
Meat and offal: 1 day.
Milk: Zero hours.