Pharmacotherapeutic group:
Anthelmintics, benzimidazole derivatives - fenbendazole.
ATC Vet Code:
QP52AC13
Pharmacodynamic properties
Fenbendazole is an anthelmintic belonging to the benzimidazole-carbamate group. It acts by interfering with the energy metabolism of the nematode or cestode.
Fenbendazole inhibits the polymerisation of tubulin to microtubules. This interferes with essential structural and functional properties of the cells of helminths, such as formation of the cytoskeleton, formation of the mitotic spindle and the uptake and intracellular transport of nutrients and metabolic products. Fenbendazole is active and has a dose dependent activity on Heterakis gallinarum (adult stages), Ascaridia galli (adult stages), Capillaria obsignata (adult stages) and Raillietina echinobothrida (adult stages) in chickens, and activity against adult Heterakis gallinarum in pheasants.
Pharmacokinetic particulars
After oral administration fenbendazole is only partially absorbed. Following absorption, fenbendazole is rapidly metabolised in the liver mainly to its sulphoxide (oxfendazole) and further to its sulphone (oxfendazole sulphone). In chickens oxfendazole sulfone is the main component detected in plasma, accounting for about 3/4 of the total AUC (i.e. the sum of the AUC for fenbendazole, oxfendazole and oxfendazole sulphone). Fenbendazole and its metabolites are distributed throughout the body, reaching highest concentrations in the liver.
The elimination of fenbendazole and its metabolites occurs primarily via the faeces.