ATCvet code: QM01AE03
Pharmacodynamics
Ketoprofen is a non-steroidal anti-inflammatory drug. In addition to the antiinflammatory effect, it also exerts an anti-pyretic and analgesic effect. The pharmacological mechanism of action of ketoprofen is based on the inhibition of the cyclo-oxygenase and lipoxygenase. Ketoprofen also prevents the formation of bradykinin and stabilises the cell membranes of lysosomes, which inhibits the release of lysosomal enzymes that mediate tissue destruction.
Pharmacokinetics
Ketoprofen is rapidly absorbed after intramuscular administration. Maximum plasma concentration is reached within 30 to 60 minutes. Absolute bioavailability after intramuscular administration in cattle and pigs is 90 - 100%, in the horse 70%. The volume of distribution and clearance are approximately 0.17 L/kg and 0.3 L/kg respectively. Linear kinetics prevails.
The plasma half-life after intramuscular administration is 2 to 3 hours. Ketoprofen binds 95% to plasma proteins and is metabolised by reduction to the secondary alcohol. It is excreted rapidly, mainly via the urine i.e. 80% of the dose administered are eliminated within 12 hours. The reduced ketoprofen metabolite prevails in cattle, the glucuronidated conjugate in horses.
PHARMACEUTICAL PARTICULARS
Major incompatibilities
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
Shelf life
Shelf life of the veterinary medicinal product as packaged for sale: 3 years
Shelf life after first opening the immediate packaging: 28 days
Special precautions for storage
Keep the glass vial in the outer carton in order to protect from light.
After first opening the immediate packaging do not store above 25 °C.
Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Medicines should not be disposed of via wastewater.
Use take-back schemes for the disposal of any unused veterinary medicinal product or waste materials derived thereof in accordance with local requirements and with any national collection systems applicable to the veterinary medicinal product concerned.