Target species
Cats and dogs
Indications for use, specifying the target species
Symptomatic treatment of vomiting and reduced gastro-intestinal motility associated with gastritis, pyloric spasm, chronic nephritis and digestive intolerance to some drugs. Prevention of vomiting after surgery.
Contraindications
Do not use in cases of:
- gastro-intestinal perforation or obstruction.
- gastro-intestinal hemorrhage
- hypersensitivity to the active substance or to any of the excipients.
Special warnings for each target species
None
Special precautions for use
Special precautions for use in animals
The dosage must be adapted in animals with renal or hepatic insufficiency (due to an increase in the risk of side effects).
Avoid administration to animals with seizure disorders or head trauma. Avoid in dogs with pseudopregnancy.
Avoid administration to animals with epilepsy. The dosage should be carefully observed, especially in cats and small breed dogs.
In animals with pheochromocytoma, metoclopramide may induce a hypertensive crisis.
Following prolonged vomiting, consideration should be given to fluid and electrolyte replacement therapy.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Wash hands after administration to the animal.
In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician.
In case of accidental spillage onto skin or eyes, wash immediately with abundant water. If adverse effects appear, seek medical advice immediately and show the package leaflet or the label to the physician.
Special precautions for the protection of the environment Not applicable.
Other precautions:
Not applicable.
Adverse reactions (frequency and seriousness)
Dogs:
Very rare (<1 animal / 10,000 animals treated, including isolated reports): | Extrapyramidal effects (agitation, ataxia, abnormal positions and/or movements, prostration, tremors and aggression, vocalisation)* Allergic reaction |
*The observed effects are transient and disappear when treatment is stopped.
Cats:
Very rare (<1 animal / 10,000 animals treated, including isolated reports): | Extrapyramidal effects (agitation, ataxia, abnormal positions and/or movements, prostration, tremors and aggression, vocalisation)* Allergic reaction Drowsiness Diarrhoea |
*The observed effects are transient and disappear when treatment is stopped
Use during pregnancy, lactation or lay
Pregnancy and lactation:
Laboratory studies in laboratory animals have not produced any evidence of teratogenic or foetotoxic effects.
However, studies on laboratory animals are limited and the safety of the active substance has not been evaluated in the target species. Use only according to the benefit/risk assessment by the responsible veterinarian.
Interaction with other medicinal products and other forms of interaction
In cases of gastritis, avoid the co-administration of anticholinergic drugs (atropine) as they may counteract the effects of metoclopramide on gastro- intestinal motility.
In cases of simultaneous diarrhoea, there is no contraindication to the use of anticholinergic drugs.
Concurrent use of metoclopramide with neuroleptics derived from phenothiazine (acepromazine) and butyrophenones increases the risk of extrapyramidal effects (see section - Adverse reactions).
Metoclopramide can potentiate the action of central nervous system depressants. If used concurrently, it is advised to use the lowest dosage of metoclopramide to avoid excessive sedation.
Amount(s) to be administered and administration route
Intramuscular or subcutaneous use
0.5 to 1 mg of metoclopramide hydrochloride per kg of body weight per day by intramuscular or subcutaneous routes, divided in 2 or 3 administrations:
- for twice daily administration: 2.5 to 5 mg/10 kg of body weight per injection
i.e. 0.5 to 1 ml/10 kg of body weight per injection.
- for administration 3 times a day: 1.7 to 3.3 mg/10 kg of body weight per injection i.e. 0.34 to 0.66 ml/10 kg of body weight per injection.
The interval between two administrations should be at least 6 hours.
The stopper should not be punctured more than 20 times.
Overdose (symptoms, emergency procedures, antidotes), if necessary
Most of the clinical signs reported after an overdosage are well-known extrapyramidal side effects (see section - Adverse reactions).
In the absence of a specific antidote, it is recommended to offer a calm environment to the animal until extrapyramidal side effects disappear. Metoclopramide being rapidly metabolised and eliminated, side effects generally disappear quickly.
Withdrawal period(s)
Not applicable.