Pharmacodynamic properties
Flunixin meglumine is a potent, non narcotic, non steroidal analgesic agent with anti-inflammatory, antipyretic and anti-endotoxic activity.
Flunixin meglumine is a potent inhibitor of cyclo-oxygenase and thereby of the endogenous production of prostaglandins.
Flunixin has no influence on natural or per injection administered prostaglandin F2-alpha.
It has been demonstrated that flunixin has an anti-endotoxin activity, in particular against the effects of endotoxins formed by E Coli.
Pharmacokinetic properties
Absorption/Elimination
Studies in horses have shown that onset of activity occurs within 2 hours (= 15 to 60 minutes) after parenteral administration when used in musculo-skeletal disorders.
Peak response occurs between 12 and 16 hours and the duration of activity is 24-36 hours (30-40 hours).
When used in equine colic, studies have shown alleviation of pain within 15 minutes (intravenous).
The plasma half-life in horse-serum is 1.6 hours following a single dose of 1.1 mg/kg. Measurable amounts are detectable in horse plasma at eight hours post injection.
Flunixin is mainly excreted via the bile. A minor part is eliminated via the urine.
Environmental properties
Flunixin is toxic to avian scavengers although foreseen low exposure leads to low risk.