Target species
- Cattle: pre-ruminants up to 100 kg b.w.
- Pigs
Indications for use for each target species
In cattle and pigs
Indicated in the treatment of respiratory infections caused by susceptible strains of organisms.
Contraindications
None.
Special warnings
None.
Special precautions for use
Special precautions for safe use in the target species:
Official and local antimicrobial policies should be taken into account when the product is used. Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials. Whenever possible, fluoroquinolones should only be used based on susceptibility testing. Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
People with known hypersensitivity to fluoroquinolones, such as marbofloxacin, should avoid contact with this veterinary medicinal product. Wash hands after use.
Special precautions for the protection of the environment:
Manure and slurry containing marbofloxacin should not be spread on the same area of land in successive years.
Adverse events
Calves and swine:
Very rare (<1 animal / 10,000 animals treated, including isolated reports): | Injection site inflammation1 |
1Transitory inflammatory reaction are sometimes observed at the injection site, but without clinical impact. No severe side-effects are to be expected at doses up to 5 times the recommended dose in cattle and pigs. In particular, no lesions of the articular joints are encountered.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Use during pregnancy, lactation or lay
Not applicable.
Interaction with other medicinal products and other forms of interaction
None known.
Administration routes and dosage
The recommended dosage is 2 mg/kg/day (1 ml/10 kg) in a single daily injection by subcutaneous or intravenous routes in cattle and by intramuscular route in pigs.
Treatment duration is as follows:
- cattle, IV route : 3 to 5 days
- cattle, SC route : 3 days
- pigs, IM route : 3 to 5 days
In order to reduce the risk of particulate contamination of the veterinary medicinal product, it is recommended that a draw-off needle be used to reduce the number of times the septum is punctured.
Symptoms of overdose (and where applicable, emergency procedures and antidotes)
Overdosage may cause acute signs in the form of neurological disorders which should be treated symptomatically.
Special restrictions for use and special conditions for use, including restrictions on the use of antimicrobial and antiparasitic veterinary medicinal products in order to limit the risk of development of resistance
Not applicable.
Withdrawal periods
Preruminating calves (up to 100kg bodyweight)
Meat and offal: 6 days
Pigs
Meat and offal: 4 days
The volume of injection should be limited to 10ml at each site of injection for pigs.