Target Species
Atlantic salmon
Indications for use
For active immunisation of Atlantic salmon to reduce mortality caused by infections with IPNV (Infectious pancreatic necrosis), Aeromonas salmonicida subsp. salmonicida (furunculosis), Aliivibrio salmonicida (cold-water vibriosis), Vibrio anguillarum serotype O1 and O2a (vibriosis), Moritella viscosa, genotype CC1 (winter ulcer disease), and Yersinia ruckeri serotype O1, biotype 1 strains (yersiniosis).
Onset of immunity: 469 degree days (dd) for M. viscosa, 500 dd for all other bacterial components, and 517 dd for IPNV.
Duration of immunity: 7 months for IPNV, and 12 months for the bacterial components.
Contraindications
None.
Special warnings for each target species
Vaccinate healthy animals only.
Special precautions for use
Vaccination is recommended for fish above 30 grams.
Feed should be withheld at least 2 days prior to vaccination. The fish should be anaesthetised before vaccination. The length and the diameter of the applied needle should be adapted to the actual fish size.
The vaccine should not be used in diseased or unhealthy fish, fish receiving medical treatment or fish during smoltification.
Do not vaccinate below 2.5 °C or above 17 °C.
Vaccination at high water temperatures (≥ 17 °C) may increase local reactions.
Incorrect vaccination, stress and poor hygiene may lead to increased adverse events.
Operator warnings
Personal protective equipment consisting of guarded needles or needle protectors should be used when administering the product.
In case of accidental self-injection, seek medical advice immediately and show the package leaflet or label to the physician.
To the user:
This veterinary medicinal product contains mineral oil. Accidental injection/self-injection may result in severe pain and swelling, particularly if injected into a joint or finger, and in rare cases could result in the loss of the affected finger if prompt medical attention is not given. If you are accidentally injected with this veterinary medicinal product, seek prompt medical advice even if only a very small amount is injected and take the package leaflet with you. If pain persists for more than 12 hours after medical examination, seek medical advice again.
To the physician:
This veterinary medicinal product contains mineral oil. Even if small amounts have been injected, accidental injection with this veterinary medicinal product can cause intense swelling, which may, for example, result in ischaemic necrosis and even the loss of a digit. Expert, PROMPT, surgical attention is required and may necessitate early incision and irrigation of the injected area, especially where there is involvement of finger pulp or tendon.
Adverse Reactions
Atlantic salmon:
Very common (>1 animal / 10 animals treated): | Adhesion in fish1, Melanin accumulation in fish, Visible vaccine in fish. Reduced growth rate2 |
Common (1 to 10 animals / 100 animals treated): | Adhesion in fish3. |
1Speilberg score of 1 and 2.
2Observed in the immediate post vaccination period.
3Speilberg score of 3.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Use during pregnancy or lactation
Fertility:
Do not use in broodstock. The possible effects of vaccination on spawning have not been investigated.
Interactions
No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product.
A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case-by-case basis.
Amounts to be administered and administration route
Intraperitoneal use.
Shake the bottle well before use. Avoid formation of air bubbles.
Dosage: a single dose of 0.05 ml.
Administration: intraperitoneally along the central line, approximately 1 pelvic fin length in front of the pelvic fin base.
Vaccination equipment must be thoroughly cleaned/sterilised before use and used by trained personnel.
It is important to ensure that air is removed from the vaccination equipment before vaccination and that the entire vaccine dose is deposited into the abdominal cavity before the needle is withdrawn. Vaccination equipment must be calibrated according to the manufacturer’s recommendations before use. Regular dose monitoring is recommended.
Overdose
Following the administration of an overdose (0.1 ml), no adverse events other than those described in section 3.6 were observed, however Speilberg scores for adhesions in fish were higher; Speilberg scores ranging from 1 to 3 were very common, and a Speilberg score of 4 was uncommon.
Withdrawal periods
Zero degree days.