The product should not be used in:
•Breeding dogs
•Animals suffering from liver or renal diseases
Adverse Reactions
A transient hypotensive effect has been observed during the first 10 minutes post-injection of atipamezole hydrochloride. In rare cases hyperactivity, tachycardia, salivation, atypical vocalisation, muscle tremor, vomiting, increased respiratory rate, uncontrolled urination and uncontrolled defecation may occur. In very rare cases recurrence of sedation may occur or the recovery time may not be shortened after administration of atipamezole.
In cats, when using low doses to partially reverse the effects of medetomidine or dexmedetomidine, the possibility of hypothermia (even when aroused from sedation) should be guarded against.
If you notice any serious effect or other effects not mentioned in this data sheet, please inform your veterinary surgeon.
Special precautions for use in animals
After administration of the product, the animals should be allowed to rest in a quiet place. During recovery time animals should not be left unattended.
Make sure that the animal has regained a normal swallowing reflex before any food or drink is offered.
Due to different dosing recommendations caution should be taken if using the product off-label in animals other than the target species.
If other sedatives than medetomidine are given it must be kept in mind that the effects of those other agents may persist after reversal of (dex)medetomidine.
Atipamezole does not reverse the effect of ketamine, which may cause seizures in dogs and elicit cramps in cats when used alone. Do not use atipamezole earlier than 30-40 minutes after concomitant administration of ketamine.
User warnings
Due to the potent pharmacological activity of atipamezole, skin–, eye- and mucous membrane- contact with this product should be avoided. In case of accidental spillage wash the affected area immediately with clean running water. Seek medical attention if irritation persists. Remove contaminated clothes that are in direct contact with the skin.
Care should be taken to avoid accidental ingestion or self-injection. If accidental ingestion or self-injection occurs, seek medical attention immediately, showing a copy of the package leaflet.
Use during pregnancy, lactation and lay
As the use of atipamezole during pregnancy and lactation has not been documented adequately, it should not be used in pregnant or lactating animals.
Interaction with other medicinal products and other forms of interaction
A simultaneous administration of atipamezole with other centrally acting medicinal products as diazepam, acepromazin or opiates is not recommended.
Overdose
Overdose of atipamezole hydrochloride may result in transient tachycardia and over-alertness (hyperactivity, muscle tremor). If necessary, these symptoms may be reversed by a (dex)medetomidine hydrochloride dose which is lower than the usually used clinical dose.
If atipamezole hydrochloride is inadvertently administered to an animal not previously treated with (dex)medetomidine hydrochloride, hyperactivity and muscle tremor may occur. These effects may persist for about 15 minutes.
Over-alertness in the cat is best handled by minimising external stimuli.
Incompatibilities
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products in the same syringe.