For the active immunisation of cattle against Infectious Bovine Rhinotracheitis (IBR), to reduce virus shedding and clinical signs including, in female cattle, abortions associated with BoHV-1 infection. A reduction in abortions associated with BoHV-1 infection has been demonstrated during the second trimester of gestation following challenge 28 days after vaccination. Vaccinated cattle can be differentiated from field virus infected animals due to the marker deletion, unless the cattle were previously vaccinated with a conventional vaccine or infected with field virus.
Onset of immunity: 7 days following a single intranasal administration.
21 days following a single intramuscular administration.
Duration of immunity following vaccination before 3 months of age: after intranasal vaccination of calves aged 2 weeks or older without maternally derived antibodies, immunity lasts until at least 3 months of age, when the animals should be revaccinated via intramuscular injection.
A proportion of young calves may have maternally derived antibodies to BoHV-1, which may affect the immune response to vaccination. Consequently, the protection afforded by the vaccine may not be complete until the revaccination at 3 months of age. Duration of immunity: following vaccination at or after 3 months of age: 6 months
Additional information on protection from abortion afforded by combined vaccination of Rispoval IBR-Marker Live with Rispoval IBR-Marker Inactivated*: prevention of abortion has been demonstrated during the third trimester of gestation upon BoHV-1 challenge applied 86 days after a single dose booster vaccination using Rispoval IBR-Marker Inactivated, which was administered 6 months after a single dose primary vaccination using Rispoval IBR-Marker Live.
*Where this veterinary medicinal product is authorised.