Dose
2 ml reconstituted vaccine.
Route of administration
Intranasal and/or intramuscular inoculation. The vaccine is injected aseptically via the intramuscular route (2 ml) or sprayed into the nostrils (1 ml per nostril during aspiration) with the intranasal applicator available from Zoetis.
Once resuspended the vaccine remains potent for max. 8 hours when the veterinary medicinal product is withdrawn sterile and refrigerated.
Vaccine reconstitution
The freeze-dried product should be reconstituted aseptically just prior to use. The vaccine is prepared as follows:
For 10 and 50 dose vials approximately 4 ml of the respective diluent are transferred into the vial containing freeze-dried pellet and mixed well.
The reconstituted virus fraction is then transferred back into the remaining diluent and mixed well. The veterinary medicinal product is then ready for use.
The needles and syringes used for application of the vaccine must not be sterilised by chemical disinfectants as this may impair the efficacy of the vaccine.
Vaccination scheme
Calves of 2 weeks to 3 months of age at first vaccination
The first vaccination should be applied intranasally, followed by a second vaccination intramuscularly at 3 months of age.
A proportion of young calves may have maternally derived antibodies to BoHV-1, which may affect the immune response to vaccination. Consequently, the protection afforded by the vaccine may not be complete until the revaccination at 3 months of age. As an extra precaution in situations of high challenge with BoHV-1, maternal antibody positive animals that have been initially vaccinated at around 2 weeks of age may be given an additional vaccination between the first vaccination and vaccination at 3 months of age. This additional vaccination may be given via either intranasal or intramuscular administration and may be given from 3 weeks after the first vaccination.
Cattle at 3 months of age or older at first vaccination
Animals should be given one intramuscular vaccination or intranasal vaccination.
Beef cattle and fattening bulls are vaccinated preferably just prior to housing (crowding) or at transfer to new groups, while taking into account the interval needed for the onset of protection following the basic vaccination scheme.
For female cattle for protection against abortion
To prevent abortions associated with BoHV-1 female cattle require a primary course of two intramuscular doses of Rispoval IBR-Marker Live 3-5 weeks apart or alternatively a primary course of a single intramuscular dose of Rispoval IBR-Marker Live followed 6 months later by a single dose booster using Rispoval IBR-Marker Inactivated. In order to cover the main abortion risk period, it is recommended that the second dose of the primary course of two intramuscular doses of Rispoval IBR-Marker Live or the single dose booster using Rispoval IBR-Marker Inactivated is administered no later than by the start of the second trimester of each pregnancy.
Cattle at immediate risk of IBR
In the case of known high BoHV-1 infection pressure, the first dose in cattle (including pregnant females) should be administered intranasally in order to stimulate local immunity followed 3-5 weeks later by the second dose administered intramuscularly to complete the primary vaccination course.
Booster vaccinations
Animals should be given a single dose booster vaccination 6 months after their initial vaccination course. Animals initially vaccinated with Rispoval IBR-Marker Live may be given a single dose booster vaccination with either Rispoval IBR-Marker Live to provide 6 months of protection or Rispoval IBR-Marker Inactivated to provide a duration of protective immunity of 12 months. Thereafter, single dose booster vaccinations should be administered every 6 months (if using Rispoval IBR-Marker Live) or every 12 months (if using Rispoval IBR-Marker Inactivated).
Vaccination schemes summary
From 2 weeks to 3 months of age |
Rispoval IBR-Marker vaccine used Primary Vaccination | Revaccination Intervals |
First dose (vaccine, route of administration) | Second dose (vaccine, route of administration) | Interval to next booster vaccination (vaccine, route of administration) | All subsequent booster vaccinations (vaccine, route of administration) |
2 weeks (Live, intranasal) | 3 months (Live, intramuscular) | 6 Months (Live, intramuscular) | 6 Months (Live, intramuscular) |
2 weeks (Live, intranasal) | 3 months (Live, intramuscular) | 6 Months (Inactivated*, subcutaneous) | 12 months (Inactivated*, subcutaneous) |
From 3 months of age |
| | |
Rispoval IBR-Marker vaccine used | Revaccination Intervals |
Primary Vaccination (number of doses, route of administration) | Interval to first booster vaccination (vaccine, route of administration) | All subsequent booster vaccinations (vaccine, route of administration) |
Live (one dose, intramuscular or intranasal) | 6 Months (Live, intramuscular) | 6 Months (Live, intramuscular) |
Live (one dose, intramuscular) | 6 Months (Inactivated*, subcutaneous) | 12 Months (Inactivated*, subcutaneous) |
Inactivated* (two doses, subcutaneous, with 3 - 5 Week Interval) | 6 Months (Inactivated*, subcutaneous) | 6 Months (Inactivated*, subcutaneous) |
For female cattle for protection against abortion: | |
| |
Rispoval IBR-Marker vaccine used | Revaccination |
Primary Vaccination (number of doses, route of administration) recommended to be applied no later than by the start of the second trimester of pregnancy |
Live (two doses, intramuscular, with 3-5 week interval) | Inactivated* (one dose, subcutaneous) recommended to be applied no later than by the start of the second trimester of each pregnancy |
Live (one dose, intramuscular) followed by Inactivated* (one dose, subcutaneous), with 6 months interval | Inactivated* (one dose, subcutaneous) recommended to be applied no later than by the start of the second trimester of each pregnancy |
Inactivated* (two doses, subcutaneous, with 3-5 week interval) | Inactivated* (one dose, subcutaneous) recommended to be applied no later than by the start of the second trimester of each pregnancy |
For vaccination in known high BoHV-1 infection pressure: |
| | |
Rispoval IBR-Marker vaccine used | Revaccination Intervals |
Primary Vaccination (number of doses, route of administration) | Interval to first booster vaccination (vaccine, route of administration) | All subsequent booster vaccinations (vaccine, route of administration) |
Live (one dose, intranasal), followed by Live (one dose, intramuscular) with 3-5 weeks interval | 6 Months (Live, intramuscular, OR Inactivated*, subcutaneous) | 6 Months (Live, intramuscular) OR 12 months (Inactivated*, subcutaneous) |
*Where this veterinary medicinal product is authorised.