ATC Vet Code: QG02AD90
Pharmacotherapeutic group
Prostaglandins
Pharmacodynamic properties
Cloprostenol, a synthetic prostaglandin analogue, structurally related to Prostaglandin F2α (PGF2α), is a potent luteolytic agent which provokes a morphological and functional regression (luteolysis) of the corpus luteum in pigs.
Pharmacokinetic particulars
After its administration by injection, cloprostenol is metabolised to acid 9α, 11α, dihydroxy-15-ceto prost-5-enoic and 9α, 11α, 15-trihydroxyprost-5-enoic which rapidly disappears from the blood, being excreted via the urine in 5-6 hours.
Radiolabel studies show blood levels between 0.0014 and 0.002 μg per ml at 20 minutes - 2 hours after its administration. Subsequently, blood levels fall rapidly, having an apparent half life of 1-3 hours, falling below 0.00004 μg/ml at 8 hours. No significant concentrations are found at 24 hours in the liver, muscle, heart, kidneys, uterus, ovaries, skin, brain and fat.