Pharmacodynamic properties
This veterinary medicinal product contains tenogenic primed equine allogeneic peripheral blood-derived mesenchymal stem cells (tpMSCs). The beneficial effects of tpMSCs were observed in an experimental tendon injury model in horses. After tpMSC administration the treated horses showed improved ultrasound echogenicity and fibre alignment scores, higher percentages of intact and fully aligned tendon fascicles, higher collagen type I to type III ratio and lower smooth muscle actin levels than horses treated with a saline control.
Pharmacokinetic particulars
After injection of the veterinary medicinal product, the tpMSCs do not migrate or distribute from the treated tendon to surrounding tissues or the draining lymph node.