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Dosage and administration
All materials used in administering the vaccine must be free of antimicrobials, detergent or disinfectant residues to prevent inactivation.
Reconstitution with solvent:
10 and 50 dose presentations: Reconstitute the vaccine by adding the full contents of the accompanying solvent to the vaccine. Shake well and use immediately.
100 dose presentation: Reconstitute the vaccine by adding half of the contents of the accompanying solvent to the vaccine. Shake well and transfer the suspension back into the solvent bottle, mix with the remaining solvent to complete to a total volume of 200 ml. Shake well and use immediately.
Visual appearance after reconstitution: light orange to pink semi-transparent suspension.
Vaccination by drench application:
Administer a single 2 ml dose orally to pigs (from 3 weeks of age), irrespective of body weight.
Vaccination via the drinking water:
The systems have to be cleaned and intensively rinsed with untreated water to avoid any residues of antimicrobials, detergents or disinfectants.
The final solution containing the vaccine should be consumed within 4 hours after preparation. Calculate the number of vials required to vaccinate all the pigs according to the table below:
No of Pigs
Vaccine vial
Solvent Vial
10 dose (20ml)
50 dose (100ml)
100 dose (100ml)
Dilute the reconstituted vaccine in drinking water on the basis of pre-measured water intake during a 4 hour time period of the previous day at the time of planned vaccination.
Pigs will generally drink 8 to 12 % of their body weight per day, depending on environmental temperatures. The actual amount of water consumed may vary considerably depending on several factors. It is essential for the efficacy of the product that pigs receive at least the recommended dose. Therefore it is recommended to assess the actual water intake over the 4 hour period the day before vaccination at same time the vaccination is planned to occur.
In case of vaccination using a trough the total water uptake within 4 hours needs to be provided. In case of vaccination via proportioner the required volume of stock solution for a 4 hours vaccination needs to be measured.
It is recommended to add skimmed milk powder or sodium thiosulfate solution as a stabilizer into the drinking water prior to adding the vaccine. The final concentration of the skimmed milk powder should be 2.5 g/litre. The final concentration of sodium thiosulfate should be approximately 0.055 g/litre.
After measuring the calculated water amount, sodium thiosulphate or skimmed milk powder should be added to the water. Afterwards, the reconstituted vaccine is to be diluted either in the water / skimmed milk or in the water / thiosulphate mixture in the trough.
Ensure that the reconstituted vaccine is evenly distributed in the water. Once even distribution has been achieved, fill the trough or the proportioner.
Vaccination via liquid feed:
The feeding systems and mixing device must be cleaned to avoid residues of antimicrobials, detergents or disinfectants.
Calculate the required number of vaccine vials as indicated in the table above.
Determine the amount of feed the animals will consume during one feeding session in less than 4 hours. The amount of feed should be defined by the feed uptake of the previous day, at the same feeding session for which the vaccination is planned.
Prepare liquid feed freshly with drinking water. The use of feed with controlled fermentation or feed containing formaldehyde is not recommended for vaccination as vaccine stability for these feed types was not tested. Reconstitute the vaccine using the provided solvent. Add the reconstituted vaccine to the fully prepared liquid feed.
Alternatively, to facilitate homogenous mixing the reconstituted vaccine may be further diluted to obtain a larger volume. This must be done with fresh drinking water containing 2.5 g/litre skimmed milk powder or 0.055 g/litre sodium thiosulfate and then mixed with the liquid feed. Ensure that the reconstituted vaccine is evenly distributed into the feed.