When used prior to ketamine induced anaesthesia, with or without halothane, a dose rate of 1 ml/100 kg (equivalent to 100 micrograms romifidine HCl/kg bodyweight ) should be used followed by 2.2 mg/kg ketamine after 5 to 10 minutes.

When used with other anaesthetic agents, a dose of 0.4 – 0.8 ml per 100 kg bodyweight has been found to be most suitable. This corresponds to 40 to 80 micrograms romifidine HCl/kg bodyweight. Anaesthesia should be induced after maximum sedation is achieved (5 – 10 minutes).