Target Species
Dogs (bitch).
Indications for use
The treatment of hormone-dependent urinary incontinence due to sphincter mechanism incompetence in ovariohysterectomised bitches.
Contraindications
Do not use in intact bitches as the efficacy has only been established in ovariohysterectomised bitches.
Do not use in animals with symptoms of polyuria-polydipsia.
Do not use in animals younger than 1 year.
Special warnings for each target species
High doses of oestrogen may have a tumour-promoting effect in target organs with oestrogen receptors (mammary glands).
Special precautions for use
In case of oestrogenic effects, the dose should be lowered.
Operator warnings
Not applicable.
Adverse Reactions
Dog (bitch):
Very common (> 1 animal / 10 animals treated): | Swollen vulva1,2, mammary gland oedema1,2, attractiveness to males1,2. Vomiting1,2. |
Rare (1 to 10 animals / 10 000 animals treated): | Vaginal haemorrhage. Alopecia. |
1 Observed at the highest recommended dose of 2 mg per dog.
2 These effects are reversible after lowering the dose.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Use during pregnancy or lactation
The use is not recommended during pregnancy or lactation.
Interactions
None known.
Amounts to be administered and administration route
Oral use.
A relationship between the final effective dose and body weight has not been established and therefore the dose must be determined for each dog on an individual basis.
Recommended dosing schedule:
Start treatment with 1 tablet (1 mg estriol) every day.
If treatment is successful, lower the dose to half a tablet per day.
If treatment is not successful, increase the dose to 2 tablets per day to be administered as a single dose.
Do not use more than 2 tablets per dog per day.
The minimum dose should not be less than half a tablet (0.5 mg estriol) per dog per day.
Ensure the dose used to achieve the therapeutic effect is as low as possible.
Some dogs do not need daily treatment. Once an effective daily dose has been established, treatment every other day may be tried.
If no response to treatment is achieved, the diagnosis should be reconsidered and other causes for the incontinence such as neurological disorders, bladder neoplasia, etc. investigated.
Animals should be re-examined every 6 months during treatment.
Overdose
In case of overdose, typical oestrogen effects may occur. These effects are reversible after lowering the dose.
Withdrawal periods
Not applicable.