ATCvet code: QG03CA04
Pharmacodynamic properties
Estriol is a short-acting natural oestrogen. In ovarioectomised female dogs it has a beneficial effect on urinary incontinence. In the target animal safety study and the clinical trials, including long-term treatment, no signs of bone marrow suppression were observed. This is probably due to the short-acting oestrogenic character of estriol.
Pharmacokinetic particulars
After oral administration, estriol is nearly completely absorbed from gastrointestinal tract. Almost all of the absorbed estriol is bound to plasma albumin.
Estriol is excreted in conjugated form via the urine.
After oral administration of multiple doses, no accumulation occurs.