Spirovac can be used during pregnancy and lactation.
Vaccination induces humoral antibody response and cell-mediated immunity as measured by serology and gamma-interferon production. A marked, statistically significant difference is also seen in the anamnestic response following a single booster vaccination or infection (challenge) 12 months after primary vaccination.
A strong serological cross-reactivity post vaccination has been demonstrated against Leptospira interrogans serovar Hardjo, a closely related species in the same serovar. This was sustained for at least 12 months following primary vaccination, and is also seen in the anamnestic response following a single booster vaccination. A challenge model is not available to document protection.