ATC Vet code QJ01EW10
Sulfadiazine is a bacterial antibiotic belonging to the sulphonamide group, which acts by inteference with the synthesis of nucleic acids. Trimethoprim is a dihydrofolate reductase inhibitor which also interferes with the synthesis of bacterial nucleic acids. Sulfadiazine and trimethoprim act on the same metabolic pathway, resulting in potentiation of antibacterial activity.
Following oral administration of sulfadiazine and trimethoprim to chickens, t ½ a and t ½ βvalues of 0.756 and 7.07 hours (sulfadiazine) and 0.680 and 6.24 hours (trimethoprim) were obtained. Values for Tmax were 2.46 and 2.44 hours, values for Cmax were 86.45 and 3.65µg/ml and values of AUC were 620.50 and 19.87 µg hour/ml, respectively for sulfadiazine and trimethoprim.