Vaccination of sows and gilts for the passive immunization of piglets against colibacillosis caused by enteropathogenic and enterotoxigenic E. coli strains expressing F4ac, F5, F6, F18ac and F41 adhesins, against oedema disease caused by E. coli strain expressing F18ab adhesin and against necrotic enteritis caused by C. perfringens type C.
Neonatal piglets
- The vaccine reduces mortality and clinical signs (severe diarrhoea) due to colibacillosis.
- The vaccine reduces mortality and clinical signs due to necrotic enteritis caused by C. perfringens type C.
Weaned piglets
- The vaccine reduces mortality and clinical signs due to oedema disease
- The vaccine reduces clinical signs (severe diarrhoea) of colibacillosis
- The vaccine reduces clinical signs of chronic enteritis due to C. perfringens type C
Duration of immunity:
− 21 days for infections caused by F4ac, F18ac (colibacillosis) and Clostridium perfringens type C (necrotic enteritis)
− 21 days for antibodies against F5, F6 and F41, however the protective efficacy of the antibody levels was not established
− 28 days for infections caused by F18ab (oedema disease)