Do not use in animals suffering from cardiac, hepatic or renal disease or gastrointestinal problems, where there is a possibility of gastrointestinal ulceration or bleeding, or hypersensitivity to carprofen or any other NSAIDs or any excipients of this veterinary medicinal product.
Do not administer by intramuscular injection.
Do not use after surgery which was associated with considerable blood loss.
Do not use in cats on repeated occasions.
Do not use in cats less than 5 months of age.
Do not use in dogs less than 10 weeks of age.
Special precautions for safe use in animals
Do not exceed the recommended dose or duration of treatment.
Due to the longer half life in cats and narrower therapeutic index, particular care should be taken not to exceed the recommended dose and the dose should not be repeated.
Use in aged dogs and cats may involve additional risk.
If such use cannot be avoided, such animals may require a reduced dosage and careful clinical management.
Avoid use in any dehydrated, hypovolaemic or hypotensive animals, as there is a potential risk of increased renal toxicity.
NSAIDs can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infection, appropriate concurrent antimicrobial therapy should be instigated.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Care should be taken to avoid accidental self-injection.
Carprofen, in common with other NSAIDs, has been shown to exhibit photosensitising potential in laboratory animals. Avoid skin contact with the veterinary medicinal product. Should this occur, wash the affected area immediately.
People with known hypersensitivity to carprofen or to any of the excipients should avoid contact with the veterinary medicinal product.
Adverse events
Dogs and cats: Rare (1 to 10 animals / 10,000 animals treated): Renal disorder Hepatic disorder1
Undetermined frequency (cannot be estimated from the available data): Vomiting2, loose stool2, diarrhoea2, blood in faeces2,3, appetite loss2, Lethargy2, Injection site reaction4.
1 - Idiosyncratic reaction.
2 - Generally occur within the first treatment week and are in most cases transient and disappear following termination of the treatment but in very rare cases may be serious or fatal.
3 - Occult
4 - Following subcutaneous injection.
If adverse reactions occur, use of the veterinary medicinal product should be stopped and the advice of a veterinarian should be sought. .
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Overdose
There is no specific antidote for carprofen overdosage but general supportive therapy as applied to clinical overdosage with NSAIDs should be applied.
Interactions with other medicinal products and other forms of interaction
Do not administer other NSAIDs and glucocorticoids concurrently or within 24 hours of administration of the veterinary medicinal product. Carprofen is highly bound to plasma proteins and may compete with other highly bound drugs, which can lead to toxic effects.
Concurrent administration of potential nephrotoxic drugs should be avoided.
In the absence of compatibility studies this veterinary medicinal product must not be mixed with other veterinary medicinal products.