Pharmacotherapeutic group: Antiinflammatory and antirheumatic products, non-steroids.
ATCvet code: QM01AE91
Carprofen possesses anti-inflammatory, analgesic and antipyretic activity. Like most other NSAID’s, carprofen is an inhibitor of the enzyme cyclo-oxygenase of the arachidonic acid cascade. However, the inhibition of prostaglandin synthesis by carprofen is slight in relation to its anti-inflammatory and analgesic potency. The precise mode of action of carprofen is not clear.
Carprofen is a chiral drug with the S(+) enantiomer being more active than the R(-) enantiomer. There is no chiral inversion between the enantiomers in-vivo.
Carprofen is well absorbed after subcutaneous administration with peak plasma concentrations achieved within 3 h after administration. The volume of distribution is small. Carprofen is highly protein bound. Carprofen is characterized by a half-life of approximately 10 hours in dogs. In cats, the elimination half-life is longer ranging from 9-49 hours after intravenous administration (mean of 20 hrs).
Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products: Medicines should not be disposed of via wastewater. Use take-back schemes for the disposal of any unused veterinary medicinal product or waste materials derived thereof in accordance with local requirements and with any national collection systems applicable to the veterinary medicinal product concerned.
List of Excipients:
Benzyl alcohol (E1519) (10 mg), Arginine Glycocholic acid, Hydrochloric acid dilute (for pH adjustment), Lecithin, Sodium hydroxide, Water for injections