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Clinical particulars
Target species
Indications for use, specifying the target species
Reduction of pyrexia in acute cases of infectious respiratory disease in cattle, in combination with appropriate anti-infective therapy.
Do not use in animals suffering from cardiac, hepatic or renal impairment.
Do not use in animals suffering from gastrointestinal ulceration or bleeding.
Do not use where there is evidence of a blood dyscrasia.
Do not use in animals with known hypersensitivity to the product.
For use in pregnant animals refer to section, "Use during pregnancy, lactation or lay"
Special warnings for each target species
Special precautions for use
Special precautions for use in animals
Do not exceed the stated dose or the duration of treatment.
Do not administer other NSAIDs concurrently or within 24 hours of each other. Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs, which can lead to toxic effects.
Use in any animal less than 6 weeks of age, or in aged animals, may involve additional risk. If such use cannot be avoided animals may require a reduced dosage and careful clinical management.
Avoid use in any dehydrated, hypovolaemic or hypotensive animal, as there is a potential risk of increased renal toxicity. Also refer to section, "Interaction with other medicinal products and other forms of interaction"
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Carprofen, in common with other NSAIDs, has been shown to exhibit photosensitising potential in laboratory studies. Avoid skin contact with the product. Wash off any splashes immediately. Take care to avoid accidental self-injection.
Adverse reactions (frequency and seriousness)
Studies in cattle have shown that a transient local reaction may form at the site of subcutaneous injection, however this should disappear within 24 hours after the injection.
Use during pregnancy, lactation or lay
The safety of the veterinary medicinal product has not been established during pregnancy. Use only accordingly to the benefit/risk assessment by the responsible veterinarian.
Interaction with other medicinal products and other forms of interaction
In common with other NSAIDs, carprofen should not be administered simultaneously with another product of the NSAID or glucocorticoid class. Animals should be carefully monitored if carprofen is administered simultaneously with an anticoagulant. NSAIDs are highly bound to plasma proteins and may compete with other highly bound drugs, which can lead to toxic effects.
Concurrent administration of potential nephrotoxic drugs should be avoided.
Amounts to be administered and administration route
Single subcutaneous or intravenous injection at a dosage of 1.4 mg carprofen per kilogram (1ml/35kg) bodyweight in combination with antibiotic therapy, as appropriate.
Do not exceed 10 broachings per vial. If more than 10 broachings are required, the use of a draw-off needle is recommended.
Overdose (symptoms, emergency procedures, antidotes), if necessary
No systemic adverse effects were reported after intravenous or subcutaneous administration of up to 3 times the recommended dose. There is no specific antidote for carprofen overdosage but general supportive therapy, as applied to clinical overdosage with NSAIDs should be applied.
Withdrawal period(s)
Milk: Zero hours.
Meat and offal: 21 days.