Indications for use, specifying the target species
For the treatment of mixed cestode and nematode or arthropod infestations, due to adult and immature roundworms, lungworms, bots and tapeworms in horses:
Strongylus vulgaris (adult and arterial larvae), Strongylus edentatus (adult and L4 tissue larval stages), Strongylus equinus (adult), Tridontophorus spp. (adult)
Cyathostomum: Cylicocyclus spp., Cylicostephanus spp., Cylicodontophorus spp., Gyalocephalus spp. (adult and non-inhibited mucosal larvae)
Parascaris: Parascaris equorum (adult and larvae)
Oxyuris: Oxyuris equi (larvae)
Trichostrongylus: Trichostrongylus axei (adult)
Strongyloides: Strongyloides westeri (adult)
Habronema: Habronema spp. (adult)
Onchocerca: Onchocerca spp. microfilariae i.e. cutaneous onchocerciasis
Lungworm: Dictyocaulus arnfieldi (adult and larvae)
Anoplocephala perfoliata (adult), Anoplocephala magna (adult), Paranoplocephala mamillana (adult)
Gasterophilus spp. (larvae)
Do not use in foals under 2 weeks of age.
Do not use in case of hypersensitivity to the active substances or to any of the excipients.
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
- Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
Resistance to ivermectin (an avermectin) has been reported in Parascaris equorum in horses in a number of countries including in the EU. Therefore the use of this product should be based on local (regional farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.
As tapeworm infestation is unlikely to occur in horses before two months of age, treatment of foals below this age is not considered necessary.
Special precautions for use
Special precautions for use in animals
Avermectins may not be well tolerated in all non target animals. Cases of intolerance are reported in dogs, especially Collies, Old English Sheepdogs and related breeds or crosses, and also in turtle and tortoises. Dogs and cats should not be allowed to ingest spilled paste or access to used syringes due to the potential for adverse effects related to ivermectin toxicity.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Wash hands after use.
Do not eat, drink or smoke while handling this product.
Avoid contact with the eyes as the product may cause eye irritation.
In case of accidental eye contact, rinse immediately with plenty of water.
In case of accidental ingestion or eye irritation, seek medical advice and show the package leaflet or label to the physician.
Adverse reactions (frequency and seriousness)
Horses carrying heavy infection of Onchocerca microfilariae have experienced such reactions as swelling and itching after treatment. It is assumed that these reactions are the result of the destruction of large numbers of microfilariae.
In case of very high levels of infestation, destruction of the parasites may cause a mild transient colic and loose faeces in the treated horse.
Colic, diarrhea and anorexia have been reported in very rare occasions post treatment, in particular when there is heavy worm burden.
In very rare occasions, allergic reactions such as hypersalivation, lingual oedema and urticaria, tachycardia, congested mucus membranes, and subcutaneous oedema have been reported following treatment with the product. A veterinarian should be consulted if these signs persist.
The frequency of adverse reactions is defined using the following convention:
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports
Use during pregnancy, lactation or lay
Can be used during pregnancy and lactation.
Interaction with other medicinal products and other forms of interaction
Amounts to be administered and administration route
For oral use. Single administration.
200 µg of Ivermectin and 1.5 mg of Praziquantel per kg of bodyweight corresponding to 1.07 g of paste per 100 kg bodyweight.
To ensure administration of a correct dose, bodyweight should be determined as accurately as possible and the correct syringe division selected, as underdosing might lead to an increased risk of development of resistance to anthelmintic drugs.
Up to 100 kg
401 – 450 kg
101 – 150 kg
451 – 500 kg
151 – 200 kg
501 – 550 kg
201 – 250 kg
551 – 600 kg
251 – 300 kg
601 – 650 kg
301 – 350 kg
651 – 700 kg
351 – 400 kg
The first division delivers enough paste to treat 50 kg.
Each subsequent syringe division delivers enough paste to treat 50 kg of bodyweight. The syringe should be adjusted to the calculated dosage by setting the ring on the appropriate place on the plunger.
The syringe contains 7.49 g of paste and delivers sufficient paste to treat 700 kg of bodyweight at the recommended dose rate.
Directions for use
Before administration, adjust the syringe to the calculated dosage by setting the ring on the plunger. The paste is administered orally by inserting the nozzle of the syringe through the interdental space and depositing the required amount of the paste on the back of the tongue. The animal’s mouth should be free of any food. Immediately after administration, elevate the head of the horse for a few seconds to ensure the dose is swallowed.
The veterinary surgeon should give advice regarding appropriate dosing programmes and stock management to achieve adequate parasite control for both tapeworm and roundworm infestations.
Overdose (symptoms, emergency procedures, antidotes), if necessary
A tolerance study performed in foals from 2 weeks of age with doses up to 5 times the recommended dosage showed no adverse reactions.
Safety studies conducted in mares administered 3 times the recommended dosage at 14 day intervals during the whole gestation and lactation did not show any abortions, any adverse effects on the gestation, parturition and on the mares general health, nor any abnormalities on the foals.
Safety studies conducted in stallions administered 3 times the recommended dosage did not show any adverse effects in particular on the reproductive performances.
Horses: Meat & Offal: 35 days
Not permitted for use in horses producing milk for human consumption.