Administration route:
In drinking water/milk use: Drinking systems should be clean and free of rust to avoid reduction of activity. In the case of cattle (pre-ruminant) it can be administered in milk or milk replacer.
Amounts to be administered:
Pigs (weaned piglets): Administer 12,500 IU apramycin sulfate per kilogram of bodyweight (corresponding to 22.5 mg of veterinary medicinal product/kg bw), daily for 7 consecutive days.
Cattle (pre-ruminant): Administer 40,000 IU apramycin sulfate per kilogram of bodyweight (corresponding to 72 mg of veterinary medicinal product/kg bw), daily for 5 consecutive days.
Chickens (broilers): Administer 80,000 IU apramycin sulfate per kilogram of bodyweight (corresponding to 144 mg of veterinary medicinal product/kg bw), daily for 5 consecutive days.
Rabbits: Administer 20,000 IU apramycin sulfate per kilogram of bodyweight (corresponding to 36 mg of veterinary medicinal product/kg bw), daily for 5 consecutive days.
The intake of medicated water depends on the clinical condition of the animals. In order to obtain the correct dose, the concentration of the has active substance may need to be adjusted accordingly. Based on the recommended dose and the number and weight of animals to be treated, the exact daily concentration of the veterinary medicinal product should be calculated according to the following formula:
Dose (mg product per kg body weight per day) | x mean body weight (kg) of animals to be treated | |
_________________________________________________________________________ | = mg product per litre of drinking water/milk |
Average daily water intake (l/animal) | |
To ensure a correct dosage, bodyweight should be determined as accurately as possible. Prepare the solution with fresh tap water (or milk/milk replacer for calves) immediately before use. Medicated drinking water should be refreshed or replaced every 24 hours. Milk replacer should be prepared prior to the addition of the powder. The solution should be vigorously stirred for 5 minutes. Medicated milk/milk replacer should be consumed immediately after preparation Water uptake should be monitored at frequent intervals during medication. In order to ensure consumption of the medicated water, animals should not have access to other water supplies whilst being treated. After the end of the medication period, the water supply system should be cleaned appropriately to avoid intake of sub-therapeutic amounts of the active substance. If it is not possible to obtain sufficient uptake of medicated water, animals should be treated parenterally (where appropriate). The maximum solubility of the product in water and milk replacer is approximately 1000 g/L. The use of suitably calibrated measuring equipment is recommended.