Pharmacodynamic properties
This product contains chondrogenic induced equine mesenchymal stem cells and equine allogeneic plasma (EAP). The addition of the EAP to the stem cells after thawing and just before injection of the product increases the viability of the stem cells. The chondrogenic induction of the mesenchymal stem cells aims to activate chondroprotective mechanisms, such as the production of extracellular matrix. In an experimental model of osteoarthritis in horses these effects were reflected through parameters related to cartilage turnover.
Pharmacokinetic particulars
After injection of the product the stem cells do not migrate or distribute from the treated joint and synovia to tissues surrounding the synovial space.